UK-2D
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Bioactive by-products |
| Catalog number | BBF-01600 |
| CAS | |
| Molecular Weight | 528.55 |
| Molecular Formula | C27H32N2O9 |
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Description
UK-2D is produced by Streptomyces sp. 517-02. Its antifungal effect is similar to that of Antimycin A3.
Properties
| Appearance | Needle Crystal |
| Antibiotic Activity Spectrum | fungi |
| Melting Point | 175-178°C |
Reference Reading
1. UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. I. Fermentation, isolation, and biological properties
M Ueki, K Abe, M Hanafi, K Shibata, T Tanaka, M Taniguchi J Antibiot (Tokyo). 1996 Jul;49(7):639-43. doi: 10.7164/antibiotics.49.639.
Novel antifungal antibiotics, UK-2A, B and a mixture of C and D, were obtained from the mycelial cake of Streptomyces sp. 517-02. All of the UK-2 compounds were similar in structure to antimycin A. The antifungal activities of UK-2 compounds were as strong as that of antimycin A. However, the UK-2 compounds demonstrated weak cytotoxicity compared to antimycin A.
2. UK-2A,B,C and D, novel antifungal antibiotics from Streptomyces sp.517.02. V. Inhibition mechanism of bovine heart mitochondrial cytochrome bc1 by the novel antibiotic UK-2A
K Machida, H Takimoto, H Miyoshi, M Taniguchi J Antibiot (Tokyo). 1999 Aug;52(8):748-53. doi: 10.7164/antibiotics.52.748.
UK-2A is a potent antifungal antibiotic isolated from Streptomyces sp. 517-02 and its structure is highly similar to that of antimycin A. We investigated the inhibition mechanism of bovine heart mitochondrial cytochrome bc1 complex by the UK-2A using antimycin A and myxothiazol as the reference inhibitors of ubiquinol oxidation (Qo) and ubiquinone reduction (Qi) sites, respectively. The inhibitory potency of UK-2A was about 3-fold less than antimycin A. On the basis of the effects of UK-2A on the reduction kinetics of b and c1 hemes, this compound appeared to be an inhibitor of the Qi site. However, since spectral changes of dithionite-reduced cytochrome b induced by UK-2A binding differed from that of antimycin A, the precise binding manner of UK-2A to the enzyme is not identical to that of antimycin A. It could be concluded that antimycin A binding to cytochrome b is primarily decided by structural specificity of the salicylic acid moiety.
3. UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. II. Structural elucidation
M Hanafi, K Shibata, M Ueki, M Taniguchi J Antibiot (Tokyo). 1996 Dec;49(12):1226-31. doi: 10.7164/antibiotics.49.1226.
UK-2A, B, C and D, novel antibiotics produced by Streptomyces sp. 517-02, exhibit strong antifungal activity. The structures were elucidated based on spectral and chemical evidence that these compounds are the derivatives of the nine-membered dilactone formed from serine and 4-hydroxypentanoic acid moiety.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
