UK-80695
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| Category | Others |
| Catalog number | BBF-03714 |
| CAS | 127346-86-5 |
| Molecular Weight | 654.83 |
| Molecular Formula | C38H54O9 |
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Description
UK-80695 is a melbemycin antibiotic produced by Streptomyces hygroscopicus. It possesses anthelmintic and ectoparasiticidal activity.
Specification
| Synonyms | UK 80695; Milbemycin B, 5-O-demethyl-28-deoxy-6,28-epoxy-13-(2-methyl-1-oxopropoxy)-25-(1-methyl-1-propenyl)-, (6R,13R,25S)- |
| IUPAC Name | [(4S,5'S,6R,6'S,8R,10E,13S,14E,16E,20R,21R,24S)-6'-[(E)-but-2-en-2-yl]-21,24-dihydroxy-5',11,13,22-tetramethyl-2-oxospiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-12-yl] 2-methylpropanoate |
| Canonical SMILES | CC=C(C)C1C(CCC2(O1)CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5O)C)C(=O)O3)O)C)OC(=O)C(C)C)C)C |
| InChI | InChI=1S/C38H54O9/c1-9-22(4)33-25(7)15-16-37(47-33)19-29-18-28(46-37)14-13-24(6)32(45-35(40)21(2)3)23(5)11-10-12-27-20-43-34-31(39)26(8)17-30(36(41)44-29)38(27,34)42/h9-13,17,21,23,25,28-34,39,42H,14-16,18-20H2,1-8H3/b11-10+,22-9+,24-13+,27-12+/t23-,25-,28+,29-,30?,31+,32?,33+,34+,37+,38+/m0/s1 |
| InChI Key | XQJPRIJOJVJRFC-VYLBHDSBSA-N |
Properties
| Antibiotic Activity Spectrum | parasites |
| Boiling Point | 787.9°C at 760 mmHg |
| Density | 1.2 g/cm3 |
Reference Reading
1. C-13 beta-acyloxymilbemycins, a new family of macrolides. Discovery, structural determination and biological properties
M A Haxell, B F Bishop, P Bryce, K A Gration, H Kara, R A Monday, M S Pacey, D A Perry, Y Kojima, H Maeda, et al. J Antibiot (Tokyo). 1992 May;45(5):659-70. doi: 10.7164/antibiotics.45.659.
A family of novel milbemycins possessing C-13 beta-acyloxy substitution was produced by Streptomyces hygroscopicus ATCC 53718. These compounds were detected by HPLC diode array analysis and possess anthelmintic and ectoparasiticidal activity. The origin of the oxygen atom at C-13 is discussed.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
