Vertimycin
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| Category | Antibiotics |
| Catalog number | BBF-02957 |
| CAS | 14477-60-2 |
| Molecular Weight | 174.19 |
| Molecular Formula | C8H14O4 |
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Description
It is a cyclopentane derivative of antibiotic produced by the strain of Streptoverticillium sp. JA 4498. It has anti-gram-positive bacteria and fungal effects. It has weak effect on Ehrlich ascites cancer cells in vitro.
Specification
| Synonyms | Cyclopentanone, 2-(2-hydroxyethoxy)-5-(hydroxymethyl)-; 1-Ethylenodiolo-3-methylolo-cyclopentanone-2; 1-(Aethylendiol-1,2)-methylol-3-cyclopentanon-2 |
| IUPAC Name | 2-(2-hydroxyethoxy)-5-(hydroxymethyl)cyclopentan-1-one |
| Canonical SMILES | C1CC(C(=O)C1CO)OCCO |
| InChI | InChI=1S/C8H14O4/c9-3-4-12-7-2-1-6(5-10)8(7)11/h6-7,9-10H,1-5H2 |
| InChI Key | AFYSAJGWEKEFIP-UHFFFAOYSA-N |
Properties
| Appearance | White Crystal |
| Antibiotic Activity Spectrum | Gram-positive bacteria; Neoplastics (Tumor); Fungi |
| Boiling Point | 358.1±32.0°C at 760 mmHg |
| Melting Point | 163-165°C |
| Density | 1.2±0.1 g/cm3 |
Reference Reading
1. Pharmacokinetics of vertilmicin, a novel aminoglycoside antibiotic, in rats and dogs
Mao-Jin Zhou, Mei-Ying Su, Ren-Zhong Wan, Chang-Xiao Liu Eur J Drug Metab Pharmacokinet. 2010 Sep;35(1-2):47-53. doi: 10.1007/s13318-010-0007-8.
The pharmacokinetics of vertilmicin was investigated in rats and dogs following intramuscular or intravenous administration of vertilmicin. Following a single administration of an intramuscular dose, serum concentrations of vertilmicin peaked at 0.63 h in rats and 0.58 h in dogs. In rats, after intravenous administration of vertilmicin at dosages of 10, 20, and 40 mg/kg, the t1/2 values for vertilmicin were 0.81, 0.76, and 0.86 h, respectively, while after intramuscular administration of vertilmicin at dose of 20 mg/kg, the t1/2 value for vertiImicin was 0.79 h. In dogs, after intravenous or intramuscular administration of vertilmicin at a dose of 10 mg/kg, the t1/2 values for vertilmicin were 0.83 and 0.85 h, respectively. After intravenous dosing to rats vertilmicin was distributed to most organs and tissues, and kidney tissue exhibited the highest exposure, while the tissue with the lowest exposure was the brain. Following single intravenous administration of vertilmicin at a dose of 20 mg/kg to rats, about 81.1% of the vertilmicin was excreted in urine, while only 3.12 and 1.44% of the administered dose was excreted in feces and bile within 48 h. The mean values for the plasma protein binding of vertilmicin were 22.7 and 20.4% in rats and dogs, respectively. These results indicate that vertilmicin was rapidly absorbed and widely distributed into various tissues in rats. The pharmacokinetic behavior of vertilmicin was dose-dependent when increasing doses of vertilmicin were administered intravenously to rats. Renal excretion was the primary elimination route of vertilmicin following intravenous administration to rats.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
