Viranamycin B
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| Category | Antibiotics |
| Catalog number | BBF-02965 |
| CAS | 139595-04-3 |
| Molecular Weight | 840.05 |
| Molecular Formula | C44H73NO14 |
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Description
It is produced by the strain of Str. sp. CH 41. It can inhibit the growth of murine leukemia cell P388 with IC50 of 2.8 ng/mL, and it can also inhibit KB human multi-squamous cell carcinoma cells with IC50 of 1.9 ng/mL.
Specification
| Synonyms | Concanamycin A, 25-de(1-propenyl)-25-methyl- |
| IUPAC Name | [(2R,3R,4S,6S)-6-[(2R,4S,5R,6R)-2-[(2S,3S,4R)-4-[(2S,3S,4E,6E,9R,10S,11R,12R,13S,14E,16Z)-11-ethyl-10,12-dihydroxy-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6,14,16-tetraen-2-yl]-3-hydroxypentan-2-yl]-2-hydroxy-5,6-dimethyloxan-4-yl]oxy-4-hydroxy-2-methyloxan-3-yl] carbamate |
| Canonical SMILES | CCC1C(C(CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C)C)OC3CC(C(C(O3)C)OC(=O)N)O)O)O)OC)C)C)O |
| InChI | InChI=1S/C44H73NO14/c1-13-31-37(47)24(4)17-22(2)15-14-16-33(53-11)40(57-42(50)34(54-12)19-23(3)18-25(5)38(31)48)27(7)39(49)28(8)44(52)21-35(26(6)29(9)59-44)56-36-20-32(46)41(30(10)55-36)58-43(45)51/h14-16,18-19,24-33,35-41,46-49,52H,13,17,20-21H2,1-12H3,(H2,45,51)/b16-14+,22-15+,23-18+,34-19-/t24-,25+,26-,27-,28+,29-,30-,31-,32+,33+,35+,36-,37+,38-,39+,40+,41+,44-/m1/s1 |
| InChI Key | IQDQMKRHOJUEEN-IFQPHJMCSA-N |
Properties
| Appearance | Colorless Powder |
| Antibiotic Activity Spectrum | Neoplastics (Tumor) |
| Boiling Point | 956.2±65.0°C at 760 mmHg |
| Melting Point | 108-109°C |
| Density | 1.2±0.1 g/cm3 |
| Solubility | Soluble in Methanol, Chloroform |
Reference Reading
1. Isolation and structural elucidation of new 18-membered macrolide antibiotics, viranamycins A and B
Y Hayakawa, K Takaku, K Furihata, K Nagai, H Seto J Antibiot (Tokyo). 1991 Dec;44(12):1294-9. doi: 10.7164/antibiotics.44.1294.
Two cytotoxic antibiotics, designated viranamycins A and B, were isolated from the culture broth of Streptomyces sp. CH41. Their structures were elucidated as new 18-membered macrolides related to virustomycin A and concanamycin A from NMR spectral analysis. Viranamycins A and B inhibited the growth of P388 mouse leukemia and KB human squamous-cell-carcinoma cells.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
