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Voriconazole

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Voriconazole
Category Bioactive by-products
Catalog number BBF-04154
CAS 137234-62-9
Molecular Weight 349.31
Molecular Formula C16H14F3N5O
Purity >98%
Catalog Number Size Price Stock Quantity
BBF-04154 10 g $298 In stock

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Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

Voriconazole is an antifungal medication used to treat a number of fungal infections, including aspergillosis, candidemia, and esophageal candidiasis.

  • Specification
  • Properties
  • Reference Reading
  • Price Product List
  • QC Data
Synonyms UK-109496; UK 109496; UK109496; UK109,496; UK-109,496; UK 109,496; Voriconazole; Vfend
Storage Store at -20°C
IUPAC Name (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol
Canonical SMILES CC(C1=NC=NC=C1F)C(CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O
InChI InChI=1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1
InChI Key BCEHBSKCWLPMDN-MGPLVRAMSA-N
Appearance White to Off-white Solid
Antibiotic Activity Spectrum fungi
Boiling Point 508.6±60.0°C at 760 mmHg
Melting Point 129-132°C
Density 1.4±0.1 g/cm3
Solubility Soluble in methanol, Acetonitrile
1.A retrospective analysis of patient-specific factors on voriconazole clearance.
Dote S1, Sawai M1, Nozaki A1, Naruhashi K2, Kobayashi Y1, Nakanishi H2. J Pharm Health Care Sci. 2016 Apr 19;2:10. doi: 10.1186/s40780-016-0044-9. eCollection 2016.
BACKGROUND: Voriconazole concentrations display a large variability, which cannot completely be explained by known factors. We investigated the relationships of voriconazole concentration with patient-specific variables and concomitant medication to identify clinical factors affecting voriconazole clearance.
2.Voriconazole pharmacokinetics following HSCT: results from the BMT CTN 0101 trial.
Hope WW1, Walsh TJ2, Goodwin J3, Peloquin CA4, Howard A5, Kurtzberg J6, Mendizabal A7, Confer DL8, Bulitta J9, Baden LR10, Neely MN11, Wingard JR4; Blood and Marrow Transplant Clinical Trials Network. J Antimicrob Chemother. 2016 Apr 27. pii: dkw127. [Epub ahead of print]
BACKGROUND: Voriconazole is a first-line agent for the prevention and treatment of a number of invasive fungal diseases. Relatively little is known about the relationship between drug exposure and the prevention of invasive fungal infections.

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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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