WA8242B
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| Category | Enzyme inhibitors |
| Catalog number | BBF-01614 |
| CAS | |
| Molecular Weight | 697 |
| Molecular Formula | C40H76N2O7 |
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Description
WA8242B is a PLA2 inhibitor produced by Steptomyces violaceusniger No. 8242.
Specification
| Synonyms | WA-8242B |
| IUPAC Name | (5S)-6-[(3S)-1-amino-15-methyl-1-oxohexadecan-3-yl]oxy-5-[[(3S)-3-hydroxy-15-methylhexadecanoyl]amino]-6-oxohexanoic acid |
| Canonical SMILES | CC(C)CCCCCCCCCCCC(CC(=O)NC(CCCC(=O)O)C(=O)OC(CCCCCCCCCCCC(C)C)CC(=O)N)O |
| InChI | InChI=1S/C40H76N2O7/c1-32(2)24-19-15-11-7-5-9-13-17-21-26-34(43)30-38(45)42-36(28-23-29-39(46)47)40(48)49-35(31-37(41)44)27-22-18-14-10-6-8-12-16-20-25-33(3)4/h32-36,43H,5-31H2,1-4H3,(H2,41,44)(H,42,45)(H,46,47)/t34-,35-,36-/m0/s1 |
| InChI Key | GBJZUVQTZBGBFB-KVBYWJEESA-N |
Reference Reading
1. WA8242A1, A2 and B, novel secretory phospholipase A2 inhibitors produced by Streptomyces violaceusniger. II. Biological properties
S Yoshimura, T Otsuka, Y Muramatsu, T Fujiwara, M Okamoto, S Hashimoto, M Okuhara J Antibiot (Tokyo). 1998 Jan;51(1):8-13. doi: 10.7164/antibiotics.51.8.
WA8242A1, A2 and B, novel inhibitors of secretory phospholipase A2 (PLA2), were obtained from Streptomyces violaceusniger No. 8242. WA8242B inhibited secretory group I and II PLA2s in a dose-dependent manner. The mode of inhibition of group II PLA2 by WA8242B was in competitive fashion. WA8242B inhibited group II PLA2-induced Prostaglandin I2 (PGI2) production by human umbilical vein endothelial cells. Furthermore, WA8242B was effective in mouse zymosan writhing model.
2. WA8242A1, A2 and B, novel secretary phospholipase A2 inhibitors produced by Streptomyces violaceusniger. III. Structure elucidation and total synthesis of WA8242B
S Yoshimura, T Otsuka, S Takase, M Okamoto, S Okada, K Hemmi J Antibiot (Tokyo). 1998 Jul;51(7):655-64. doi: 10.7164/antibiotics.51.655.
The structure of WA8242B, a potent novel inhibitor against phospholipase A2, was fully characterized by spectroscopic methods and chemical degradation. The success of total synthesis of WA8242B confirmed the structure and allowed the pharmacological study of WA8242B. The structures of WA8242A1 and A2 were also described.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
