Watasemycin A
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| Category | Antibiotics |
| Catalog number | BBF-02974 |
| CAS | |
| Molecular Weight | 352.47 |
| Molecular Formula | C16H20N2O3S2 |
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Description
It is produced by the strain of Streptomyces sp. TP-A0597. It has anti-staphylococcus aureus, bacillus subtilis, proteus bizarre and cryptococcus neoformans activity with MIC (μg/mL) of 12.5, 25.0, 0.39 and 20.0, respectively.
Specification
| Synonyms | 4-Thiazolidinecarboxylic acid, 2-[(4R,5S)-4,5-dihydro-2-(2-hydroxyphenyl)-5-methyl-4-thiazolyl]-3,4-dimethyl-, (2S,4S)- |
| IUPAC Name | (2S,4S)-2-[(4R,5S)-2-(2-hydroxyphenyl)-5-methyl-4,5-dihydro-1,3-thiazol-4-yl]-3,4-dimethyl-1,3-thiazolidine-4-carboxylic acid |
| Canonical SMILES | CC1C(N=C(S1)C2=CC=CC=C2O)C3N(C(CS3)(C)C(=O)O)C |
| InChI | InChI=1S/C16H20N2O3S2/c1-9-12(14-18(3)16(2,8-22-14)15(20)21)17-13(23-9)10-6-4-5-7-11(10)19/h4-7,9,12,14,19H,8H2,1-3H3,(H,20,21)/t9-,12+,14-,16+/m0/s1 |
| InChI Key | NOEXPDVJQLSPPC-UODBANLJSA-N |
Properties
| Appearance | Light Yellow Powder |
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria; Yeast |
| Boiling Point | 548.6±60.0°C at 760 mmHg |
| Melting Point | 62-65°C |
| Density | 1.4±0.1 g/cm3 |
| Solubility | Soluble in Methanol, Chloroform |
Reference Reading
1. Watasemycins A and B, new antibiotics produced by Streptomyces sp. TP-A0597
Omomitsu Sasaki, Yasuhiro Igarashi, Noriko Saito, Tamotsu Furumai J Antibiot (Tokyo). 2002 Mar;55(3):249-55. doi: 10.7164/antibiotics.55.249.
Two novel antibiotics, watasemycins A and B, were isolated from the fermentation broth of an actinomycete strain. The producing strain TP-A0597 was isolated from the seawater sample collected in Toyama Bay, Japan and identified as Streptomyces sp. based on the taxonomic study. The new antibiotics were obtained by solvent extraction and chromatographic purification and spectroscopic analyses identified that they were new analogs of thiazostatins. Watasemycin possesses a methyl group at 5'-position of thiazostatin instead of a hydrogen atom. Watasemycins showed antibiotic activity against Gram-positive and negative bacteria and yeast.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
