WF-2421
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| Category | Enzyme inhibitors |
| Catalog number | BBF-01621 |
| CAS | 128429-19-6 |
| Molecular Weight | 404.4 |
| Molecular Formula | C19H20N2O8 |
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Description
WF-2421 is an aldose reductase inhibitor produced by Humicola grisea.
Specification
| Synonyms | WF 2421 |
| IUPAC Name | 2-formamido-3-[3-[5-(2-formamido-1-hydroxyethyl)-2-hydroxyphenyl]-4-hydroxyphenyl]-3-hydroxypropanoic acid |
| Canonical SMILES | C1=CC(=C(C=C1C(CNC=O)O)C2=C(C=CC(=C2)C(C(C(=O)O)NC=O)O)O)O |
| InChI | InChI=1S/C19H20N2O8/c22-8-20-7-16(26)10-1-3-14(24)12(5-10)13-6-11(2-4-15(13)25)18(27)17(19(28)29)21-9-23/h1-6,8-9,16-18,24-27H,7H2,(H,20,22)(H,21,23)(H,28,29) |
| InChI Key | WQVWUCSBLUJLNT-UHFFFAOYSA-N |
Properties
| Appearance | White Powder |
| Melting Point | 220°C (dec.) |
Reference Reading
1. WF-2421, a new aldose reductase inhibitor produced from a fungus, Humicola grisea
M Nishikawa, Y Tsurumi, H Murai, K Yoshida, M Okamoto, S Takase, H Tanaka, H Hirota, M Hashimoto, M Kohsaka J Antibiot (Tokyo). 1991 Feb;44(2):130-5. doi: 10.7164/antibiotics.44.130.
WF-2421 is a novel aldose reductase inhibitor produced by Humicola grisea. WF-2421 was purified from the culture filtrate by successive ion exchange chromatography and the chemical structure was assigned to be alpha-formamido-5'-(2-formamido-1-hydroxyethyl)- beta,2',6-trihydroxy-3-biphenylpropanoic acid (1) on the basis of spectroscopic evidence. The IC50 value of WF-2421 was 3 x 10(-8) M against partially purified aldose reductase of rabbit lens.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
