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WF-3405

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WF-3405
Category Antibiotics
Catalog number BBF-01623
CAS 108354-43-4
Molecular Weight 236.22
Molecular Formula C9H16O7

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

WF-3405 is an antitumor antibiotic isolated from the culture of Amauroascus aureus F-3405. It inhibits various murine tumors including leukemia P388, leukemia L1210 and Lewis lung carcinoma.

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  • Properties
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Synonyms Antibiotic WF 3405; WF 3405
IUPAC Name 1,5-bis(oxiran-2-yl)pentane-1,2,3,4,5-pentol
Canonical SMILES C1C(O1)C(C(C(C(C(C2CO2)O)O)O)O)O
InChI InChI=1S/C9H16O7/c10-5(3-1-15-3)7(12)9(14)8(13)6(11)4-2-16-4/h3-14H,1-2H2
InChI Key LUCBFMMOZUJPIX-UHFFFAOYSA-N
Appearance Crystal
Antibiotic Activity Spectrum neoplastics (Tumor)
Melting Point 157-159°C
1. WF-3405, a novel antitumor antibiotic. Taxonomy, isolation, structure elucidation and biological properties
S Kiyoto, H Murai, Y Tsurumi, H Terano, M Kohsaka, S Takase, I Uchida, M Hashimoto, H Aoki, H Imanaka J Antibiot (Tokyo). 1987 Mar;40(3):290-5. doi: 10.7164/antibiotics.40.290.
A new antitumor antibiotic, WF-3405 was isolated from the culture of Amauroascus aureus F-3405. The structure has been determined as 1,5-dioxiranyl-1,2,3,4,5-pentanepentanol on the basis of spectroscopic and chemical evidence. WF-3405 exhibits strong inhibitory activity against various murine tumors including leukemia P388, leukemia L1210 and Lewis lung carcinoma.

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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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