WF-3405
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| Category | Antibiotics |
| Catalog number | BBF-01623 |
| CAS | 108354-43-4 |
| Molecular Weight | 236.22 |
| Molecular Formula | C9H16O7 |
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Description
WF-3405 is an antitumor antibiotic isolated from the culture of Amauroascus aureus F-3405. It inhibits various murine tumors including leukemia P388, leukemia L1210 and Lewis lung carcinoma.
Specification
| Synonyms | Antibiotic WF 3405; WF 3405 |
| IUPAC Name | 1,5-bis(oxiran-2-yl)pentane-1,2,3,4,5-pentol |
| Canonical SMILES | C1C(O1)C(C(C(C(C(C2CO2)O)O)O)O)O |
| InChI | InChI=1S/C9H16O7/c10-5(3-1-15-3)7(12)9(14)8(13)6(11)4-2-16-4/h3-14H,1-2H2 |
| InChI Key | LUCBFMMOZUJPIX-UHFFFAOYSA-N |
Properties
| Appearance | Crystal |
| Antibiotic Activity Spectrum | neoplastics (Tumor) |
| Melting Point | 157-159°C |
Reference Reading
1. WF-3405, a novel antitumor antibiotic. Taxonomy, isolation, structure elucidation and biological properties
S Kiyoto, H Murai, Y Tsurumi, H Terano, M Kohsaka, S Takase, I Uchida, M Hashimoto, H Aoki, H Imanaka J Antibiot (Tokyo). 1987 Mar;40(3):290-5. doi: 10.7164/antibiotics.40.290.
A new antitumor antibiotic, WF-3405 was isolated from the culture of Amauroascus aureus F-3405. The structure has been determined as 1,5-dioxiranyl-1,2,3,4,5-pentanepentanol on the basis of spectroscopic and chemical evidence. WF-3405 exhibits strong inhibitory activity against various murine tumors including leukemia P388, leukemia L1210 and Lewis lung carcinoma.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
