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WF11899B

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Category Antibiotics
Catalog number BBF-01629
CAS
Molecular Weight 1159.3
Molecular Formula C51H82N8O20S

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

WF11899B is a lipopeptide antibiotic isolated from the culture broth of Coleophoma empetri F-11899. It shows antifungal activity against Candida spp.

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  • Properties
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Synonyms WF-11899B
Antibiotic Activity Spectrum fungi
Melting Point 218-223°C
1. WF11899A, B and C, novel antifungal lipopeptides. II. Biological properties
T Iwamoto, A Fujie, K Nitta, S Hashimoto, M Okuhara, M Kohsaka J Antibiot (Tokyo). 1994 Oct;47(10):1092-7. doi: 10.7164/antibiotics.47.1092.
WF11899A, B and C, novel water-soluble lipopeptides related to the echinocandins, possess potent anti-Candida activities. The IC50s of the compounds against four clinical isolates of Candida albicans ranged from 0.004 to 0.03 microgram/ml by microbroth dilution assay. These compounds mildly suppressed the growth of Aspergillus fumigatus and A. niger. WF11899A, B and C showed a potent in vivo anti-Candida activity. Particularly, WF11899A was superior to cilofungin, and equal to fluconazole. 1,3-beta-glucan synthase was inhibited by these compounds at the IC50s of 0.7, 0.7 and 1.8 micrograms/ml for WF11899A, B and C, respectively. However, they hemolysed mouse red blood cells in vitro at the concentration of 62 micrograms/ml.

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