WF11899C
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| Category | Antibiotics |
| Catalog number | BBF-01630 |
| CAS | |
| Molecular Weight | 1143.3 |
| Molecular Formula | C51H82N8O19S |
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Description
WF11899C is a lipopeptide antibiotic isolated from the culture broth of Coleophoma empetri F-11899. It shows antifungal activity against Candida spp.
Specification
| Synonyms | WF-11899C |
Properties
| Antibiotic Activity Spectrum | fungi |
| Melting Point | 208-217°C |
Reference Reading
1. WF11899A, B and C, novel antifungal lipopeptides. II. Biological properties
T Iwamoto, A Fujie, K Nitta, S Hashimoto, M Okuhara, M Kohsaka J Antibiot (Tokyo). 1994 Oct;47(10):1092-7. doi: 10.7164/antibiotics.47.1092.
WF11899A, B and C, novel water-soluble lipopeptides related to the echinocandins, possess potent anti-Candida activities. The IC50s of the compounds against four clinical isolates of Candida albicans ranged from 0.004 to 0.03 microgram/ml by microbroth dilution assay. These compounds mildly suppressed the growth of Aspergillus fumigatus and A. niger. WF11899A, B and C showed a potent in vivo anti-Candida activity. Particularly, WF11899A was superior to cilofungin, and equal to fluconazole. 1,3-beta-glucan synthase was inhibited by these compounds at the IC50s of 0.7, 0.7 and 1.8 micrograms/ml for WF11899A, B and C, respectively. However, they hemolysed mouse red blood cells in vitro at the concentration of 62 micrograms/ml.
2. WF11899A, B and C, novel antifungal lipopeptides. I. Taxonomy, fermentation, isolation and physico-chemical properties
T Iwamoto, A Fujie, K Sakamoto, Y Tsurumi, N Shigematsu, M Yamashita, S Hashimoto, M Okuhara, M Kohsaka J Antibiot (Tokyo). 1994 Oct;47(10):1084-91. doi: 10.7164/antibiotics.47.1084.
WF11899A, B and C, novel antifungal lipopeptide antibiotics were isolated from the culture broth of Coleophoma empetri F-11899. These compounds belong to the echinocandin type of lipopeptides. Of these compounds, WF11899A showed good solubility in water. These three antibiotics possess potent in vitro antifungal activities against Candida spp.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
