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WF14861

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Category Enzyme inhibitors
Catalog number BBF-01631
CAS
Molecular Weight 422.5
Molecular Formula C20H30N4O6

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Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

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Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

WF14861 is a cathepsins B and L inhibitor obtained from the culture mycelium of a fungus strain Colletotrichum sp. No. 14861.

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Synonyms WF 14861; WF-14861
IUPAC Name (2S,3S)-3-[[(2S)-1-[4-aminobutyl(3-aminopropyl)amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]carbamoyl]oxirane-2-carboxylic acid
Canonical SMILES C1=CC(=CC=C1CC(C(=O)N(CCCCN)CCCN)NC(=O)C2C(O2)C(=O)O)O
InChI InChI=1S/C20H30N4O6/c21-8-1-2-10-24(11-3-9-22)19(27)15(12-13-4-6-14(25)7-5-13)23-18(26)16-17(30-16)20(28)29/h4-7,15-17,25H,1-3,8-12,21-22H2,(H,23,26)(H,28,29)/t15-,16-,17-/m0/s1
InChI Key GRBXFTOUISIXRP-ULQDDVLXSA-N
Appearance Amorphous Powder
1. WF14861, a new cathepsins B and L inhibitor produced by Colletotrichum sp. I. Taxonomy, production, purification and structure elucidation
T Otsuka, Y Muramatsu, T Higaki, T Nakanishi, S Takase, H Hatanaka, M Okamoto, M Hino, S Hashimoto J Antibiot (Tokyo). 1999 Jun;52(6):536-41. doi: 10.7164/antibiotics.52.536.
WF14861, a novel cathepsins B and L inhibitor, was obtained from the culture mycelium of a fungus strain Colletotrichum sp. No. 14861. Spectroscopic analysis showed that WF14861 consisted of trans-epoxysuccinic acid, L-tyrosine and spermidine, WF14861 inhibited cathepsins B and L selectively.
2. WF14861, a new cathepsins B and L inhibitor produced by Colletotrichum sp. II. Biological properties
T Otsuka, Y Muramatsu, K Niikura, M Okamoto, M Hino, S Hashimoto J Antibiot (Tokyo). 1999 Jun;52(6):542-7. doi: 10.7164/antibiotics.52.542.
WF14861, 3-(N-(1-(N-(4-aminobutyl)-N-(3-aminopropyl)carbamoyl)-2-(4-hydroxyphenyl )ethyl)carbamoyl)oxirane-2-carboxylic acid, was obtained from the culture mycelium of Colletotrichum sp. as a novel cathepsins B and L inhibitor. WF14861 also showed inhibitory activities against bone derived crude protease and other cysteine proteases in vitro. The compound ameliorated the tissue damage and the bone destruction models of low-calcium-diet-fed mouse and adjuvant arthritis rat model.

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