WF14865A
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Enzyme inhibitors |
| Catalog number | BBF-01632 |
| CAS | |
| Molecular Weight | 367.4 |
| Molecular Formula | C16H25N5O5 |
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Description
WF14865A is a cathepsins B and L inhibitor with IC50 of 8.4 X 10(-9) and 6.6 X 10(-8) mol/L, respectively. It is produced by Aphanoascus fulvescens.
Specification
| Synonyms | WF-14865A |
Properties
| Appearance | Colorless Powder |
Reference Reading
1. WF14865A and B, new cathepsins B and L inhibitors produced by Aphanoascus fulvescens. I. Taxonomy, production, purification and biological properties
T Otsuka, Y Muramatsu, T Nakanishi, H Hatanaka, M Okamoto, M Hino, S Hashimoto J Antibiot (Tokyo). 2000 May;53(5):449-58. doi: 10.7164/antibiotics.53.449.
WF14865A and B, novel cathepsins B and L inhibitors, were produced and isolated separately from the culture mycelium of a fungal strain Aphanoascus fulvescens No. 14865. Spectroscopic analysis revealed that both WF14865A and B were composed of trans-epoxysuccinyl moieties, 1-H-imidazole-2-ylamine, and isoleucine or leucine. These compounds inhibited human cathepsins B and L with IC50 values in the range of 8.4 approximately 72nM in vitro. Though their in vitro properties were typical as trans-epoxysuccinyl type inhibitors, they exerted strong bone resorption inhibitory effects in low-calcium-diet-fed mouse model at 3.2 approximately 10 mg/kg.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
