Wilforlide A
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| Category | Others |
| Catalog number | BBF-05807 |
| CAS | 84104-71-2 |
| Molecular Weight | 454.68 |
| Molecular Formula | C30H46O3 |
| Purity | ≥98% |
Ordering Information
| Catalog Number | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| BBF-05807 | 20 mg | $299 | In stock |
Online Inquiry
Add to cartDescription
Wilforlide A is extracted from the herb of Tripterygium wilfordii Hook.f. It has obvious anti-inflammatory effect at high-dose.
Specification
| Synonyms | Regelide; Abruslactone A; (3β,22α)-3-Hydroxy-22,29-epoxyolean-12-en-29-one; Wilforlide; Olean-12-en-29-oic acid, 3,22-dihydroxy-, γ-lactone, (3β,20α,22α)-; 3-epiabruslactone A |
| Shelf Life | 2 month in rt, long time |
| Storage | Store at -20°C |
| IUPAC Name | (1S,2R,5S,6R,9R,11S,14R,15R,19S,21S)-11-hydroxy-2,5,6,10,10,14,21-heptamethyl-23-oxahexacyclo[19.2.1.02,19.05,18.06,15.09,14]tetracos-17-en-22-one |
| Canonical SMILES | CC1(C2CCC3(C(C2(CCC1O)C)CC=C4C3(CCC5(C4CC6(CC5OC6=O)C)C)C)C)C |
| InChI | InChI=1S/C30H46O3/c1-25(2)20-10-13-30(7)21(28(20,5)12-11-22(25)31)9-8-18-19-16-26(3)17-23(33-24(26)32)27(19,4)14-15-29(18,30)6/h8,19-23,31H,9-17H2,1-7H3/t19-,20-,21+,22-,23-,26-,27+,28-,29+,30+/m0/s1 |
| InChI Key | HHQJBWYXBWOFJY-YLXTXNMFSA-N |
Properties
| Appearance | White Powder |
| Application | Wilforlide A has obvious anti-inflammatory effect at high-dose, but has no significant immune suppressive activity. |
| Boiling Point | 555.0±50.0 °C | Condition: Press: 760 Torr |
| Melting Point | 318-320 °C |
| Flash Point | 208.6 °C |
| Density | 1.12±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr |
| Solubility | Soluble in DMSO, Methanol |
Reference Reading
1.Simultaneous determination of triptolide, wilforlide A and triptonide in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry.
Yao J1, Zhang L, Zhao X, Hu L, Jiang Z. Biol Pharm Bull. 2006 Jul;29(7):1483-6.
A simple and sensitive method for the determination of triptolide, wilforlide A and triptonide in human plasma was developed and validated, using high-performance liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS). Plasma samples were purified using solid-phase extraction (SPE) columns. The HPLC separation of the analytes was performed on a MACHEREY-NAGEL C(18)column (2.0 mm x 125 mm, 3 microm), using 2.7 mM formic acid containing 10 mM ammonium acetate-acetonitrile (55:45, v/v) as mobile phase, with a flow-rate of 0.25 ml/min. The compounds were ionized in the electrospray ionization (ESI) ion source of the mass spectrometer and were detected in the selected ion recording (SIR) mode. The calibration curves were linear in the 0.80-300 ng/ml range for all the three analytes, and the limits of detection were 0.25, 0.40, and 0.35 ng/ml for triptolide, wilforlide A, and triptonide, respectively. The average absolute recoveries for all the three analytes were above 81%.
2.Comparative study on the anti-inflammatory and immune suppressive effect of Wilforlide A.
Xue M1, Jiang ZZ, Liu JP, Zhang LY, Wang T, Wang H, Liu L, Zhou ZX. Fitoterapia. 2010 Dec;81(8):1109-12. doi: 10.1016/j.fitote.2010.07.007. Epub 2010 Jul 16.
Tripterygium Glycosides (TG) is effective in the treatment of patients with a variety of inflammatory and autoimmune diseases, especially rheumatoid arthritis (RA) in clinical. Wilforlide A (T(1)) serves as a quality control standard of TG that be listed in Drug Standard of Ministry of Public Health of the People's Republic of China. The pharmacologic actions of T(1) remain to be unidentified. In this paper, we studied the anti-inflammatory and immune suppressive effect of T(1), and compared it with Triptolide (TP), which believed to be the major active component of TG. Carrageenan-induced rat pedal swelling, tampon-induced rat granulation, and mice ear inhibition rate of swelling trail results show that high-dose T(1) has obvious anti-inflammatory effect. Colorimetric detection contents of hemolysin, carbon elimination from plasma of mice, mice delayed hypersensitivity immune, and organ index were measured. The results show that T(1) has no significant immune suppressive activity, and there has a significant difference with TP and TG.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
