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WS 1358A1

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Category Enzyme inhibitors
Catalog number BBF-01641
CAS
Molecular Weight 265.13
Molecular Formula C7H9NO7Na2

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

WS 1358A1 is a dehydropeptide (DHP) inhibitor produced by Streptomyces parvulus.

  • Specification
  • Properties
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Synonyms WS-1358A1
Melting Point 98-100°C
1. Studies on new dehydropeptidase inhibitors. II. Structural elucidation and synthesis of WS1358A1 and B1
S Takase, I Uchida, S Hashimoto, H Tanaka, M Hashimoto J Antibiot (Tokyo). 1990 Jan;43(1):38-42. doi: 10.7164/antibiotics.43.38.
The structures of WS1358A1 and B1, new dehydropeptidase inhibitors isolated from Streptomyces parvulus subsp. tochigiensis No. 1358, have been established to be 2-hydroxy-2-hydroxyaminocarbonyl-3-methylglutaric acid (1) and 2-hydroxy-2-hydroxyaminocarbonylglutaric acid (2), respectively, on the basis of spectroscopic evidence and synthesis of the racemates.
2. Studies on new dehydropeptidase inhibitors. III. Biological properties of WS1358A1
S Hashimoto, H Murai, K Nitta, A Fujie, M Okuhara, M Kohsaka, H Imanaka J Antibiot (Tokyo). 1990 Mar;43(3):281-5. doi: 10.7164/antibiotics.43.281.
WS1358A1, a novel inhibitor of renal dehydropeptidase (DHP), augmented the urinary recovery of a carbapenem antibiotic imipenem and improved its protective effect in experimental infections when simultaneously administered to mice with the antibiotic. WS1358A1 was a competitive DHP inhibitor with a Ki value of 1.6 x 10(-7) M.
3. Studies on new dehydropeptidase inhibitors. I. Taxonomy, fermentation, isolation and physico-chemical properties
S Hashimoto, H Murai, M Ezaki, N Morikawa, H Hatanaka, M Okuhara, M Kohsaka, H Imanaka J Antibiot (Tokyo). 1990 Jan;43(1):29-37. doi: 10.7164/antibiotics.43.29.
WS1358A1 (FR104007) and B1 (FR104008), new potent inhibitors of renal dehydropeptidase, were isolated from the culture broth of strain No. 1358 which was identified as Streptomyces parvulus subsp. In vitro inhibitory activities (IC50 value) of WS1358A1 and B1 against porcine renal DHP were 3 and 600 nM, respectively.

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