WS 1358B1
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Enzyme inhibitors |
| Catalog number | BBF-01642 |
| CAS | 117703-85-2 |
| Molecular Weight | 251.1 |
| Molecular Formula | C6H7NO7Na2 |
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Description
WS 1358B1 is a dehydropeptide (DHP) inhibitor produced by Streptomyces parvulus.
Specification
| Synonyms | WS-1358B1 |
| IUPAC Name | 2-hydroxy-2-(hydroxycarbamoyl)pentanedioic acid |
| Canonical SMILES | C(CC(C(=O)NO)(C(=O)O)O)C(=O)O |
| InChI | InChI=1S/C6H9NO7/c8-3(9)1-2-6(13,5(11)12)4(10)7-14/h13-14H,1-2H2,(H,7,10)(H,8,9)(H,11,12) |
| InChI Key | HUZCUQQKMFUHKG-UHFFFAOYSA-N |
Properties
| Melting Point | 92-93°C |
Reference Reading
1. Studies on new dehydropeptidase inhibitors. I. Taxonomy, fermentation, isolation and physico-chemical properties
S Hashimoto, H Murai, M Ezaki, N Morikawa, H Hatanaka, M Okuhara, M Kohsaka, H Imanaka J Antibiot (Tokyo). 1990 Jan;43(1):29-37. doi: 10.7164/antibiotics.43.29.
WS1358A1 (FR104007) and B1 (FR104008), new potent inhibitors of renal dehydropeptidase, were isolated from the culture broth of strain No. 1358 which was identified as Streptomyces parvulus subsp. In vitro inhibitory activities (IC50 value) of WS1358A1 and B1 against porcine renal DHP were 3 and 600 nM, respectively.
2. Studies on new dehydropeptidase inhibitors. IV. Chemical transformation of WS1358 compounds and an improved synthesis of WS1358A1
I Uchida, S Hashimoto, T Iwamoto, S Takase, M Hashimoto J Antibiot (Tokyo). 1990 Apr;43(4):344-51. doi: 10.7164/antibiotics.43.344.
The structures of compounds 3 (and 4) and 5 (and 6) derived from the natural products WS1358A1 (1) (and B1 (2)) have been determined by their spectroscopic evidence. By taking advantage of these transformations, an improved synthesis of A1 (1, racemate) has been achieved.
3. Studies on new dehydropeptidase inhibitors. II. Structural elucidation and synthesis of WS1358A1 and B1
S Takase, I Uchida, S Hashimoto, H Tanaka, M Hashimoto J Antibiot (Tokyo). 1990 Jan;43(1):38-42. doi: 10.7164/antibiotics.43.38.
The structures of WS1358A1 and B1, new dehydropeptidase inhibitors isolated from Streptomyces parvulus subsp. tochigiensis No. 1358, have been established to be 2-hydroxy-2-hydroxyaminocarbonyl-3-methylglutaric acid (1) and 2-hydroxy-2-hydroxyaminocarbonylglutaric acid (2), respectively, on the basis of spectroscopic evidence and synthesis of the racemates.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
