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WS-7338 B

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WS-7338 B
Category Bioactive by-products
Catalog number BBF-01647
CAS
Molecular Weight 612.72
Molecular Formula C31H44N6O7

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

WS-7338 B is an endothelin receptor antagonist isolated from fermentation broth of Streptomyces sp. No. 7338. It showed good activity in an endothelin receptor binding assay with an IC50 of 2.7 x 10(-7) M.

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1. WS-7338, new endothelin receptor antagonists isolated from Streptomyces sp. No. 7338. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities
S Miyata, M Hashimoto, Y Masui, M Ezaki, S Takase, M Nishikawa, S Kiyoto, M Okuhara, M Kohsaka J Antibiot (Tokyo). 1992 Jan;45(1):74-82. doi: 10.7164/antibiotics.45.74.
WS-7338 A, B, C and D, novel endothelin receptor antagonists, have been isolated from fermentation broth of Streptomyces sp. No. 7338. These antagonists were purified from the culture mycelium by extraction with acetone, followed by carbon column chromatography and HPLC. Among them, WS-7338 B showed good activity in an endothelin receptor binding assay with an IC50 of 2.7 x 10(-7) M.
2. WS-7338, new endothelin receptor antagonists isolated from Streptomyces sp. No. 7338. II. Biological characterization and pharmacological characterization of WS-7338 B
S Miyata, M Hashimoto, K Fujie, M Nishikawa, S Kiyoto, M Okuhara, M Kohsaka J Antibiot (Tokyo). 1992 Jan;45(1):83-7. doi: 10.7164/antibiotics.45.83.
WS-7338, produced by Streptomyces sp. No. 7338, was found to be a competitive and specific antagonist against ET-1 receptors in in vitro studies and WS-7338 B is also active in vivo. Furthermore, WS-7338 B was a specific antagonist for vascular ET-1 receptors (ETA receptors) and significantly prevented the accumulation of intracellular inositol 1,4,5-triphosphate (IP3) in endothelin treated rat aorta tissues.

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