WS-7338 C
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| Category | Bioactive by-products |
| Catalog number | BBF-01648 |
| CAS | |
| Molecular Weight | 612.72 |
| Molecular Formula | C31H44N6O7 |
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Description
WS-7338 C is an endothelin receptor antagonist isolated from fermentation broth of Streptomyces sp. No. 7338.
Specification
| IUPAC Name | 3-[(2R,5S,8S,11R,14S)-14-(1H-indol-3-ylmethyl)-5-methyl-8,11-bis(2-methylpropyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propanoic acid |
| Canonical SMILES | CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCC(=O)O)CC2=CNC3=CC=CC=C32)CC(C)C)CC(C)C |
| InChI | InChI=1S/C31H44N6O7/c1-16(2)12-23-29(42)36-24(13-17(3)4)30(43)37-25(14-19-15-32-21-9-7-6-8-20(19)21)31(44)34-22(10-11-26(38)39)28(41)33-18(5)27(40)35-23/h6-9,15-18,22-25,32H,10-14H2,1-5H3,(H,33,41)(H,34,44)(H,35,40)(H,36,42)(H,37,43)(H,38,39)/t18-,22+,23-,24+,25-/m0/s1 |
| InChI Key | HDXCQTKSXNYXGI-WXJVVRSYSA-N |
Properties
| Appearance | White Powder |
Reference Reading
1. WS-7338, new endothelin receptor antagonists isolated from Streptomyces sp. No. 7338. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities
S Miyata, M Hashimoto, Y Masui, M Ezaki, S Takase, M Nishikawa, S Kiyoto, M Okuhara, M Kohsaka J Antibiot (Tokyo). 1992 Jan;45(1):74-82. doi: 10.7164/antibiotics.45.74.
WS-7338 A, B, C and D, novel endothelin receptor antagonists, have been isolated from fermentation broth of Streptomyces sp. No. 7338. These antagonists were purified from the culture mycelium by extraction with acetone, followed by carbon column chromatography and HPLC. Among them, WS-7338 B showed good activity in an endothelin receptor binding assay with an IC50 of 2.7 x 10(-7) M.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
