WS-7338 D

WS-7338 D

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Category Bioactive by-products
Catalog number BBF-01649
CAS
Molecular Weight 584.7
Molecular Formula C29H40N6O7

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Description

WS-7338 D is an endothelin receptor antagonist isolated from fermentation broth of Streptomyces sp. No. 7338.

Specification

IUPAC Name 3-[(2R,5S,8S,11R,14S)-14-(1H-indol-3-ylmethyl)-5-methyl-3,6,9,12,15-pentaoxo-8,11-di(propan-2-yl)-1,4,7,10,13-pentazacyclopentadec-2-yl]propanoic acid
Canonical SMILES CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCC(=O)O)CC2=CNC3=CC=CC=C32)C(C)C)C(C)C
InChI InChI=1S/C29H40N6O7/c1-14(2)23-28(41)33-21(12-17-13-30-19-9-7-6-8-18(17)19)27(40)32-20(10-11-22(36)37)26(39)31-16(5)25(38)34-24(15(3)4)29(42)35-23/h6-9,13-16,20-21,23-24,30H,10-12H2,1-5H3,(H,31,39)(H,32,40)(H,33,41)(H,34,38)(H,35,42)(H,36,37)/t16-,20+,21-,23+,24-/m0/s1
InChI Key DSYDICXVMGUOGE-UWLAMGOFSA-N

Properties

Appearance White Powder

Reference Reading

1. WS-7338, new endothelin receptor antagonists isolated from Streptomyces sp. No. 7338. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities
S Miyata, M Hashimoto, Y Masui, M Ezaki, S Takase, M Nishikawa, S Kiyoto, M Okuhara, M Kohsaka J Antibiot (Tokyo). 1992 Jan;45(1):74-82. doi: 10.7164/antibiotics.45.74.
WS-7338 A, B, C and D, novel endothelin receptor antagonists, have been isolated from fermentation broth of Streptomyces sp. No. 7338. These antagonists were purified from the culture mycelium by extraction with acetone, followed by carbon column chromatography and HPLC. Among them, WS-7338 B showed good activity in an endothelin receptor binding assay with an IC50 of 2.7 x 10(-7) M.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
g/mol
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