X-14847

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Category Antibiotics
Catalog number BBF-01664
CAS 75802-23-2
Molecular Weight 341.31
Molecular Formula C12H23NO10

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Description

X-14847 is an aminoglycoside antibiotic isolated from Micromonospora echinospora. It shows weak activity against gram-positive bacteria.

Specification

Synonyms X 14847; 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside; 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol
IUPAC Name (1R,2R,4S,5R)-6-[(2R,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycyclohexane-1,2,3,4,5-pentol
Canonical SMILES C(C1C(C(C(C(O1)OC2C(C(C(C(C2O)O)O)O)O)N)O)O)O
InChI InChI=1S/C12H23NO10/c13-3-5(16)4(15)2(1-14)22-12(3)23-11-9(20)7(18)6(17)8(19)10(11)21/h2-12,14-21H,1,13H2/t2-,3-,4-,5-,6?,7-,8+,9-,10-,11?,12-/m1/s1
InChI Key HEPUIGACZYVUCD-XFVWJBEHSA-N

Reference Reading

1. Microbial products. IV. X-14847, a new aminoglycoside from Micromonospora echinospora
H Maehr, C M Liu, T Hermann, B L Prosser, J M Smallheer, N J Palleroni J Antibiot (Tokyo). 1980 Dec;33(12):1431-6. doi: 10.7164/antibiotics.33.1431.
Micromonospora echinospora strain X-14847 produces gentamicin A as the major antibiotic together with a new aminoglycoside, termed X-14847, and identified as a 2-amino-2-deoxy-alpha-D-glucopyranosyl myo-inositol. This report describes the taxonomy of the culture, fermentation conditions, the isolation and the identification of X-14847.

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