YF-0200R-A
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| Category | Enzyme inhibitors |
| Catalog number | BBF-01678 |
| CAS | 156368-99-9 |
| Molecular Weight | 228.28 |
| Molecular Formula | C12H20O4 |
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Description
YF-0200R-A is a pepstatin A-sensitive Candida albicans aspartyl protease inhibitor produced by Streptomyces sp. YF-0200R. It inhibits aspartyl protease from Candida albicans with IC50 value of 6.5 x 10(-4) M.
Specification
| Synonyms | YF 0200R-A; YF 0200R A; 8,12-Dihydroxy-2,4-dodecadienoic acid |
| IUPAC Name | (2E,4E)-8,12-dihydroxydodeca-2,4-dienoic acid |
| Canonical SMILES | C(CCO)CC(CCC=CC=CC(=O)O)O |
| InChI | InChI=1S/C12H20O4/c13-10-6-5-8-11(14)7-3-1-2-4-9-12(15)16/h1-2,4,9,11,13-14H,3,5-8,10H2,(H,15,16)/b2-1+,9-4+ |
| InChI Key | GVIMYWNWIIWNBB-NTBXYKKJSA-N |
Reference Reading
1. Novel aspartyl protease inhibitors, YF-0200R-A and B
T Sato, K Nagai, M Shibazaki, K Abe, Y Takebayashi, B Lumanau, R M Rantiatmodjo J Antibiot (Tokyo). 1994 May;47(5):566-70. doi: 10.7164/antibiotics.47.566.
Novel pepstatin A-sensitive Candida albicans aspartyl protease inhibitors, named YF-0200R-A and B, were isolated by column chromatography and preparative HPLC from the fermentation broth of Streptomyces sp. YF-0200R. The structures of YF-0200R-A and B were elucidated by spectroscopic analysis as alpha, beta and gamma, delta unsaturated fatty acids with two or three hydroxyl groups. YF-0200R-A and B inhibit aspartyl protease from Candida albicans with IC50 values of 6.5 x 10(-4) M and 6.2 x 10(-4) M, respectively.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
