YF-0200R-B
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| Category | Enzyme inhibitors |
| Catalog number | BBF-01679 |
| CAS | 156369-00-5 |
| Molecular Weight | 244.28 |
| Molecular Formula | C12H20O5 |
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Description
YF-0200R-B is a pepstatin A-sensitive Candida albicans aspartyl protease inhibitor produced by Streptomyces sp. YF-0200R. It inhibits aspartyl protease from Candida albicans with IC50 value of 6.2 x 10(-4) M.
Specification
| Synonyms | YF 0200R-B; YF 0200R B; 8,10,12-trihydroxydodeca-2,4-dienoic acid |
| IUPAC Name | (2E,4E)-8,10,12-trihydroxydodeca-2,4-dienoic acid |
| Canonical SMILES | C(CC(CC(CCO)O)O)C=CC=CC(=O)O |
| InChI | InChI=1S/C12H20O5/c13-8-7-11(15)9-10(14)5-3-1-2-4-6-12(16)17/h1-2,4,6,10-11,13-15H,3,5,7-9H2,(H,16,17)/b2-1+,6-4+ |
| InChI Key | ILXMCVVGRWTBIT-ZMVSMXTFSA-N |
Properties
| Melting Point | 143-145°C |
Reference Reading
1. Novel aspartyl protease inhibitors, YF-0200R-A and B
T Sato, K Nagai, M Shibazaki, K Abe, Y Takebayashi, B Lumanau, R M Rantiatmodjo J Antibiot (Tokyo). 1994 May;47(5):566-70. doi: 10.7164/antibiotics.47.566.
Novel pepstatin A-sensitive Candida albicans aspartyl protease inhibitors, named YF-0200R-A and B, were isolated by column chromatography and preparative HPLC from the fermentation broth of Streptomyces sp. YF-0200R. The structures of YF-0200R-A and B were elucidated by spectroscopic analysis as alpha, beta and gamma, delta unsaturated fatty acids with two or three hydroxyl groups. YF-0200R-A and B inhibit aspartyl protease from Candida albicans with IC50 values of 6.5 x 10(-4) M and 6.2 x 10(-4) M, respectively.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
