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YM-32890 B

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Category Antibiotics
Catalog number BBF-01685
CAS
Molecular Weight 540.7
Molecular Formula C33H48O6

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Fermentation Lab

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2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

YM-32890 B is a macrolide antibiotic isolated from the fermentation broth of cytophaga sp. YL-02905S.

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Synonyms YM-32890B; YM-32890-B
IUPAC Name (7E,15E,19E)-4,6,12,18-tetrahydroxy-21-methyl-10-methylidene-22-[(2Z,4Z,6E)-3-methylnona-2,4,6,8-tetraenyl]-1-oxacyclodocosa-7,15,19-trien-2-one
Canonical SMILES CC1C=CC(CC=CCCC(CC(=C)CC=CC(CC(CC(=O)OC1CC=C(C)C=CC=CC=C)O)O)O)O
InChI InChI=1S/C33H48O6/c1-5-6-7-9-13-25(2)18-21-32-27(4)19-20-28(34)15-10-8-11-16-29(35)22-26(3)14-12-17-30(36)23-31(37)24-33(38)39-32/h5-10,12-13,17-20,27-32,34-37H,1,3,11,14-16,21-24H2,2,4H3/b7-6+,10-8+,13-9-,17-12+,20-19+,25-18-
InChI Key QETZYFKPMZHAFT-NWFTXAHQSA-N
Appearance Syrup Matter
1. YM-32890 A and B, new types of macrolide antibiotics produced by Cytophaga sp
K Kamigiri, T Tokunaga, T Sugawara, K Nagai, M Shibazaki, B Setiawan, R M Rantiatmodjo, M Morioka, K Suzuki J Antibiot (Tokyo). 1997 Jul;50(7):556-61. doi: 10.7164/antibiotics.50.556.
Two new types of macrolide antibiotics, YM-32890 A and B, have been isolated from the fermentation broth of cytophaga sp. YL-02905S. In this paper, the taxonomy of the producing strain, fermentation, isolation, structure elucidation, and biological activity of the antibiotics are reported. YM-32890 A inhibits the growth of staphylococci including a macrolide-resistant strain, but shows no antimicrobial activity against other Gram-positive, Gram-negative bacteria and yeast.
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