YM-47515
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| Category | Antibiotics |
| Catalog number | BBF-01688 |
| CAS | |
| Molecular Weight | 311.4 |
| Molecular Formula | C17H29NO4 |
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Description
YM-47515 is an isonitrile antibiotic isolated from Micromonospora echinospora subsp. Echinospora. It is effective against gram-positive bacteria including MRSA.
Specification
| Synonyms | YM 47515 |
| IUPAC Name | (13S)-13-hydroxy-13-[(2S,3R)-3-isocyano-3-methyloxiran-2-yl]tridecanoic acid |
| Canonical SMILES | CC1(C(O1)C(CCCCCCCCCCCC(=O)O)O)[N+]#[C-] |
| InChI | InChI=1S/C17H29NO4/c1-17(18-2)16(22-17)14(19)12-10-8-6-4-3-5-7-9-11-13-15(20)21/h14,16,19H,3-13H2,1H3,(H,20,21)/t14-,16-,17+/m0/s1 |
| InChI Key | CPFRNLPNIWVHAU-BHYGNILZSA-N |
Properties
| Antibiotic Activity Spectrum | Gram-positive bacteria |
Reference Reading
1. YM-47515, a novel isonitrile antibiotic from Micromonospora echinospora subsp. echinospora
T Sugawara, A Tanaka, H Imai, K Nagai, K Suzuki J Antibiot (Tokyo). 1997 Nov;50(11):944-8. doi: 10.7164/antibiotics.50.944.
During the course of our screening for new antibiotics, Micromonospora echinospora subsp. echinospora Y-03559J was found to produce a novel isonitrile compound, YM-47515 (1) along with a probable degradation product 2. The structure of 1 was assigned by spectroscopic analysis including 2D NMR and IR experiments. The relative stereochemistry of 1 was also proposed by comparison of spectral data with those of a closely related compound aerocyanidin (3). YM-47515 (1) showed promising antimicrobial activity against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA).
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
