Actinomycetes Fermentation Services
As a leading CDMO, BOC Sciences provides Actinomycetes fermentation services. We have the expertise and resources to provide our customers with compounds such as antibiotics, vitamins, enzymes, and other custom products from Actinomycetes at competitive prices.
Contact us today to learn more about our Actinomycetes fermentation services.
Introduction of Actinomycetes Fermentation
Actinomycetes are Gram-positive bacteria found in soil and are widely distributed in nature. Actinomycetes are important models of bacterial development and they display a complex life cycle with different cellular morphologies of spores, vegetative mycelium and reproductive mycelium, which are closely related to physiological differentiation. Notably, the production of secondary metabolites in Actinomycetes is strictly dependent on cellular morphology and physiological differentiation. Actinomycetes have an extensive library of metabolites, including antibiotics,vitamins, amino acids, nucleotides, enzymes and other compounds. Actinomycetes fermentation has been used for the production of a wide range of bioactive secondary metabolites in industry. Because of their unique enzymatic group, Actinomycetes are also a major source for the discovery of new natural products with potentially multiple uses.
Examples of fermentation products of Actinomycetes
| Metabolites | Actinomycetes | |
|---|---|---|
| β-Lactams | Penicillin | S. lipmanii, S. microflavus, S. cattleya |
| Cephalosporines | S. microflavus, S. clavuligerus, S. cinnamonensis, Amycolatopsis lactamdurans | |
| Carbapenems | S. cattleya, S. penemifaciens, S. flavogriseus, S. olivaceus | |
| Monobactam | Nocardia uniformis, Streptomyces, Actinosynnema mirum, Microtetraspora caesia | |
| Tetracyclines | Tetracycline | S. aureofaciens, S. avellaneus, S. lusitanus, S.viridifaciens |
| Chlortetracycline | S. lusitanus, S. aureofaciens | |
| Oxytetracycline | S. alboflavus, Streptomyces albofaciens, S. griseus, S. platensis | |
| 6-demethyltetracycline | S. aureofaciens | |
| Aminoglycosides | Streptomycin | S. griseus, S. streptomycinii, S. subrutilus, S. mashuensis |
| Neomycin | S. fradiae, S. catenulae, S. chrestomyceticus, S. albogriseolus | |
| Tobramycin | Streptoalloteichus hindustanus, S. tenebrarius, S. cremeus | |
| Kanamycin | S. kanamyceticus | |
| Paromomycin | S. catenulae, S. chrestomyceticus, S. rimosus, S. fradiae | |
| Gentamycin | Micromonospora purpurea, Micromonospora pallida | |
| Antimicrobial Peptides | Glycopeptides | Amycolatopsis orientalis |
| Lipopeptides | Streptomyces, S. roseosporus, S. lividans | |
| Streptogramins | S. halstedii, S. pristinaespiralis, S. virginiae | |
Advantages of Actinomycetes Fermentation
- Cultivation: Actinomycetes are adapted to a wide range of environments such as soil, water (even salty) and air, and are able to grow over a wide range of temperatures and pH values.
- Production: Actinomycetes are capable of producing antibiotics, and a variety of other secondary metabolites under specific conditions and growth media. Most of the current natural antibiotics are produced by Actinomycetes.
- Species: There are many valuable species among Actinomycetes, including Streptomyces, Actinomyces, and Micromonospora. In addition, marine Actinomycetes have unique metabolic and genetic characteristics and are a promising source of new bioactive compounds.
Applications of Actinomycetes Fermentation
- Actinomycetes have a strong ability to produce secondary metabolites, and the vast majority of antibiotics used in medicine are derived from Actinomycetes, covering a wide range of aminoglycosides, β-lactams, glycopeptides, macrolides, and tetracyclines.
- Some Actinomycetes can form biofilms enabling them to degrade complex polymers in the environment for bioremediation applications.
- Actinomycetes produce vitamins and various enzymes, including proteases, lipases and amylases, through fermentation. For example, α amylase starch degrading amylolytic enzymes are widely used in the food, textile and paper industries.
Our Services for Actinomycetes Fermentation
- Actinomycetes as host strain, strain improvement and selection
- Actinomycetes fermentation process development
- Fermentation process scale-up and microbial production
- Isolation, purification and characterization of target compounds
BOC Sciences' Actinomycetes Fermentation
- Actinomycete fermentation production, from antibiotics to industrial enzymes
- Complete quality management system with ISO 9001 certification
- Patented and proprietary manufacturing methods
- State-of-the-art facilities and aseptic products
- Total fermentation capacity of over 2,000,000 liters
Reference
- Simeis, D. D. and Serra, S., Actinomycetes: A Never-Ending Source of Bioactive Compounds—An Overview on Antibiotics Production, Antibiotics (Basel), 2021, 10(5): 483.
