Actinomycetes Fermentation Services

As a leading CDMO, BOC Sciences provides Actinomycetes fermentation services. We have the expertise and resources to provide our customers with compounds such as antibiotics, vitamins, enzymes, and other custom products from Actinomycetes at competitive prices.

Introduction of Actinomycetes Fermentation

Actinomycetes are Gram-positive bacteria found in soil and are widely distributed in nature. Actinomycetes are important models of bacterial development and they display a complex life cycle with different cellular morphologies of spores, vegetative mycelium and reproductive mycelium, which are closely related to physiological differentiation. Notably, the production of secondary metabolites in Actinomycetes is strictly dependent on cellular morphology and physiological differentiation. Actinomycetes have an extensive library of metabolites, including antibiotics,vitamins, amino acids, nucleotides, enzymes and other compounds. Actinomycetes fermentation has been used for the production of a wide range of bioactive secondary metabolites in industry. Because of their unique enzymatic group, Actinomycetes are also a major source for the discovery of new natural products with potentially multiple uses.

Examples of fermentation products of Actinomycetes

Metabolites		Actinomycetes
β-Lactams	Penicillin	S. lipmanii, S. microflavus, S. cattleya
	Cephalosporines	S. microflavus, S. clavuligerus, S. cinnamonensis, Amycolatopsis lactamdurans
	Carbapenems	S. cattleya, S. penemifaciens, S. flavogriseus, S. olivaceus
	Monobactam	Nocardia uniformis, Streptomyces, Actinosynnema mirum, Microtetraspora caesia
Tetracyclines	Tetracycline	S. aureofaciens, S. avellaneus, S. lusitanus, S.viridifaciens
	Chlortetracycline	S. lusitanus, S. aureofaciens
	Oxytetracycline	S. alboflavus, Streptomyces albofaciens, S. griseus, S. platensis
	6-demethyltetracycline	S. aureofaciens
Aminoglycosides	Streptomycin	S. griseus, S. streptomycinii, S. subrutilus, S. mashuensis
	Neomycin	S. fradiae, S. catenulae, S. chrestomyceticus, S. albogriseolus
	Tobramycin	Streptoalloteichus hindustanus, S. tenebrarius, S. cremeus
	Kanamycin	S. kanamyceticus
	Paromomycin	S. catenulae, S. chrestomyceticus, S. rimosus, S. fradiae
	Gentamycin	Micromonospora purpurea, Micromonospora pallida
Antimicrobial Peptides	Glycopeptides	Amycolatopsis orientalis
	Lipopeptides	Streptomyces, S. roseosporus, S. lividans
	Streptogramins	S. halstedii, S. pristinaespiralis, S. virginiae

Advantages of Actinomycetes Fermentation

Cultivation: Actinomycetes are adapted to a wide range of environments such as soil, water (even salty) and air, and are able to grow over a wide range of temperatures and pH values.
Production: Actinomycetes are capable of producing antibiotics, and a variety of other secondary metabolites under specific conditions and growth media. Most of the current natural antibiotics are produced by Actinomycetes.
Species: There are many valuable species among Actinomycetes, including Streptomyces, Actinomyces, and Micromonospora. In addition, marine Actinomycetes have unique metabolic and genetic characteristics and are a promising source of new bioactive compounds.

Applications of Actinomycetes Fermentation

Actinomycetes have a strong ability to produce secondary metabolites, and the vast majority of antibiotics used in medicine are derived from Actinomycetes, covering a wide range of aminoglycosides, β-lactams, glycopeptides, macrolides, and tetracyclines.
Some Actinomycetes can form biofilms enabling them to degrade complex polymers in the environment for bioremediation applications.
Actinomycetes produce vitamins and various enzymes, including proteases, lipases and amylases, through fermentation. For example, α amylase starch degrading amylolytic enzymes are widely used in the food, textile and paper industries.

Our Services for Actinomycetes Fermentation

Actinomycetes as host strain, strain improvement and selection
Actinomycetes fermentation process development
Fermentation process scale-up and microbial production
Isolation, purification and characterization of target compounds

BOC Sciences' Actinomycetes Fermentation

Actinomycete fermentation production, from antibiotics to industrial enzymes
Complete quality management system with ISO 9001 certification
Patented and proprietary manufacturing methods
State-of-the-art facilities and aseptic products
Total fermentation capacity of over 2,000,000 liters

Reference

Simeis, D. D. and Serra, S., Actinomycetes: A Never-Ending Source of Bioactive Compounds—An Overview on Antibiotics Production, Antibiotics (Basel), 2021, 10(5): 483.