Aerobic Fermentation

As a leading CDMO, BOC Sciences offers tailored solutions for aerobic fermentation to meet the specific needs of each client. Whether it's the production of enzymes, organic acids, APIs, or other bioproducts, we have the capabilities and facilities to scale up aerobic fermentation processes from laboratory-scale to pilot-scale and ultimately to commercial production.

Our Aerobic Fermentation Services

Fermentation Process Design and Optimization

Designing fermentation processes requires selecting appropriate raw materials and optimizing conditions like temperature, humidity, and oxygen supply.

Specific fermentation strategies designed for various raw material types.

Fermentation Equipment Supply and Technical Support

The supply chain includes high-temperature aerobic fermenters along with intelligent fermentation equipment and adjacent support systems like ventilation and temperature control.

Microbial Strain Development

Efficient aerobic microbial strains are provided to boost organic matter decomposition rates and improve fermentation performance.

Microbial strain formulas designed to meet specific fermentation requirements.

Product Extraction and Purification

Our company offers purification services to separate fermentation products including organic acids, proteins, and biogas.

Technical support directed at the extraction of high-value-added products including bio-fertilizers and feed additives.

Environmental Protection and Sustainable Development Services

Eco-friendly fermentation solutions help lower greenhouse gas emissions while preventing secondary pollution from occurring.

The program promotes green agricultural development through efficient agricultural waste resource utilization.

Laboratory R&D to Industrial-Scale Production

Fermentation services extend from laboratory testing to full industrial production to meet unique customer requirements.

Our technical support spans across all production stages from pilot testing through to full-scale operations.

Aerobic Fermentation Service Workflow

• Raw Material Pretreatment

Sort and crush fermentation materials; adjust moisture content and carbon-to-nitrogen (C/N) ratio.

Ensure moisture content is within an appropriate range (e.g., 40%-65%) and add necessary fermentation microbial strains.

• Fermentation Stages

Mesophilic Phase: During the initial stage, the temperature gradually rises and microbial activity begins.

Thermophilic Phase: The temperature reaches its peak; microorganisms break down organic matter and release heat.

Maturation Phase: As the temperature decreases, microbial activity slows, and organic matter becomes more stabilized.

• Post-Treatment

Remove impurities and conduct necessary crushing processes.

Perform granulation, packaging, and prepare products for dispatch according to requirements.

• Equipment and Technical Support

Provide high-temperature aerobic fermentation tanks, stirring equipment, and ventilation systems.

Monitor temperature, humidity, and oxygen concentration in real time to ensure a stable fermentation process.

Advantages of Aerobic Fermentation Services

High Efficiency and Stability: Optimized fermentation conditions and equipment reduce fermentation cycles and boost production efficiency.

Environmentally Friendly and Low-Carbon: Reduces landfill and incineration of waste, enabling resource recycling.

High-Value Products: Fermentation products can be applied in agriculture, feed, energy, and other sectors, enhancing economic benefits.

Customized Solutions: Tailored services based on client needs to meet the requirements of various industries.

Techniques in Aerobic Fermentation

Genetic Engineering

Genetic engineering is used for the modification of microbial strains to enhance their metabolic capabilities, productivity, and tolerance to process conditions, including gene knockout, gene overexpression, and metabolic pathway engineering.

Downstream Processing

Downstream processing techniques are employed to recover and purify the desired products from the fermentation broth, including filtration, centrifugation, chromatography, extraction, and drying.

Fermentation Process Control

Monitoring and controlling various parameters are crucial for optimizing aerobic fermentation. Process control systems enable real-time monitoring, data acquisition, and automated control of the fermentation process.

Analytical Techniques

Analytical techniques are used to monitor the progress of aerobic fermentation and assess the quality of the product, including spectrophotometry, HPLC, GC, MS, and enzyme assays.

Microorganisms in Aerobic Fermentation

Aerobic microorganisms possess specific enzymes, such as catalase and superoxide dismutase, which help them utilize oxygen for respiration. Aerobic microorganisms play essential roles in industrial bioprocessing, human health and environmental processes. The metabolic activities of these microorganisms in the presence of oxygen contribute to production of valuable products, the breakdown of organic matter, and maintenance of ecological balance.

Application of Aerobic Fermentation Services

1. Agriculture

Transforming organic waste (e.g., straw, livestock and poultry manure) into high-quality organic fertilizer via aerobic fermentation to improve soil structure and increase crop yield and quality.

2. Environmental Protection

Using aerobic fermentation to treat organic waste, reduce greenhouse gas emissions, avoid secondary pollution from landfilling or incineration, and achieve resource utilization.

3. Animal Feed

Converting agricultural by-products (e.g., corn cobs, sawdust) into high-protein feed through aerobic fermentation, enhancing animal immunity and growth while reducing feed costs.

4. Energy

Producing biomass energy (e.g., biogas, biomethane) through aerobic fermentation for power generation or heating, promoting the development and utilization of clean energy.

Aerobic Fermentation Products

• ATP (Adenosine Triphosphate)
• Nucleotides
• Intermediates of the Citric Acid Cycle
• Amino Acids
• Lipids
• Organic Acids
• NADPH and NADH
• Glycerol

FAQs

1. What should I do if the temperature is too high during fermentation?

You can reduce the temperature by increasing ventilation or adjusting the turning frequency of the compost pile.

2. How can I ensure the quality of the fermentation products?

Strictly control fermentation conditions (such as temperature, humidity, and oxygen supply) and use high-quality microbial strains.

3. What if there is insufficient oxygen during fermentation?

Increase ventilation or adjust stirring speed to ensure adequate oxygen supply.

4. How can I control the energy consumption of fermentation equipment?

Choose energy-efficient equipment and optimize operating parameters (e.g., air flow rate, stirring speed) to reduce energy waste.

5. How should the fermentation products be handled afterward?

They can be granulated and packaged for use as organic fertilizers or high value-adde