Aerobic Fermentation

As a leading CDMO, BOC Sciences offers tailored solutions for aerobic fermentation to meet the specific needs of each client. Whether it's the production of enzymes, organic acids, APIs, or other bioproducts, we have the capabilities and facilities to scale up aerobic fermentation processes from laboratory-scale to pilot-scale and ultimately to commercial production.

What is Aerobic Fermentation?

Aerobic fermentation refers to a metabolic process in which microorganisms convert organic compounds, such as carbohydrates, into valuable products in the presence of oxygen. Unlike anaerobic fermentation, which occurs in the absence of oxygen, aerobic fermentation relies on the supply of oxygen to sustain the growth of microorganisms.

Aerobic fermentation process:

• Oxygen supply
• Inoculation and growth
• Metabolic activity
• Product formation (e.g., biodiesel, organic acids, enzyme)
• Monitoring and control
• Harvesting and recovery

Our Aerobic Fermentation Services

• Aerobic bacteria selection
• Aerobic fermentation process development
• Aerobic fermentation products purification
• Fermentation process scale-up

Techniques in Aerobic Fermentation

Genetic Engineering

Genetic engineering is used for the modification of microbial strains to enhance their metabolic capabilities, productivity, and tolerance to process conditions, including gene knockout, gene overexpression, and metabolic pathway engineering.

Downstream Processing

Downstream processing techniques are employed to recover and purify the desired products from the fermentation broth, including filtration, centrifugation, chromatography, extraction, and drying.

Fermentation Process Control

Monitoring and controlling various parameters are crucial for optimizing aerobic fermentation. Process control systems enable real-time monitoring, data acquisition, and automated control of the fermentation process.

Analytical Techniques

Analytical techniques are used to monitor the progress of aerobic fermentation and assess the quality of the product, including spectrophotometry, HPLC, GC, MS, and enzyme assays.

Microorganisms in Aerobic Fermentation

Aerobic microorganisms possess specific enzymes, such as catalase and superoxide dismutase, which help them utilize oxygen for respiration. Aerobic microorganisms play essential roles in industrial bioprocessing, human health and environmental processes. The metabolic activities of these microorganisms in the presence of oxygen contribute to production of valuable products, the breakdown of organic matter, and maintenance of ecological balance.

Aerobic Fermentation Products

• ATP (Adenosine Triphosphate)
• Nucleotides
• Intermediates of the Citric Acid Cycle
• Amino Acids
• Lipids
• Organic Acids

• NADPH and NADH
• Glycerol

Advantages of Aerobic Fermentation

• The presence of oxygen allows microorganisms to maximize their metabolic activities, leading to higher cell densities and faster product formation. This results in increased productivity and reduced fermentation times.
• Aerobic fermentation offers a greater variety of product options due to the broader range of metabolic pathways available to microorganisms.
• The process of aerobic fermentation eliminates the need for complex anaerobic systems and the associated issues of waste management and gas buildup.

Why Choose BOC Sciences?

• Equiped special bioreactors used for aerobic fermentation
• Facilitated process control and monitoring of key parameters
• Efficient oxygen transfer system such as oxygen enrichment techniques
• Strict sterilization from unwanted microbes contamination
• High-efficiency green separation technology
• Complex product separation and purification