Fermentation for Bioactive Metabolites

BOC Sciences provides custom fermentation services for bioactive metabolites, such as antibiotics, enzyme inhibitors, mycotoxins, and other biologically active by-products. In addition, we offer an extensive product portfolio of these metabolites from milligram to kilogram scale. Our strong microbial fermentation capability of metabolites supports our customers to explore the potential applications of bioactive molecules in the fields of medicine, agriculture, graziery, environment, pharmaceutical, and food industries.

Introduction

In biochemistry, the metabolite is an intermediate or end product of metabolism. Primary metabolites, also known as the central metabolites, such as lactic acid and certain amino acids, directly participate in the normal growth, development, and reproduction of the organism. Conversely, secondary metabolites, also called specialized metabolites, are not directly involved in those processes but usually have an important biologically active role.

Moreover, secondary metabolites are usually produced by bacteria or fungi that preserved enormous biological activities, mainly in the pharmaceutical and cosmetics, food, agriculture and farming fields. Among all, antibiotics are the best known secondary metabolites. However, the production of these valuable metabolites in nature is minimum. Thus, restoration of microbial fermentation technology is necessary to achieve industrial production of these secondary metabolites.

Application of Metabolites

Metabolites have various functions, including fuel, stimulatory and inhibitory effects on enzymes, and catalytic activity. They usually act as a cofactor to an enzyme and interact with other organisms. These metabolites revealed significant potential for various industrial applications.

In the pharmaceutical industry, microbial fermentation has been the preferred solution for active pharmaceutical ingredients (APIs) production, which economically provides safer and more effective medicines.

In the food industry, fermentation processes produce a wide range of critical metabolic products, such as fatty acids, sugars, and bioactive peptides that improve food quality, flavor, and safety.

In the agriculture field, microbes contribute to plant nutrition by converting essential macromolecules into biofertilizers for plants. In addition, specific metabolites produced by microbial fermentation can protect plants from other invasive, parasitic plants and pests, such as herbicides and pesticides.

Our Product Portfolio of Metabolites

We offer an extensive product portfolio of metabolites from milligram to kilogram scale. Our strong microbial fermentation capability of metabolites supports our customers to explore the potential applications of bioactive molecules in the fields of medicine, agriculture, graziery, environment, pharmaceutical, and food industries.

Product Name	CAS No.	Area	Inquiry
Selamectin	220119-17-5	Anti-parasitic	Inquiry
Doramectin	117704-25-3	Anti-parasitic	Inquiry
Ivermectin	70288-86-7	Anti-parasitic	Inquiry
Pimecrolimus	137071-32-0	Anti-inflammatory	Inquiry
Fidaxomicin	873857-62-6	Antibiotic	Inquiry
Gramicdin A	11029-61-1	Antibiotic	Inquiry
Gramicidin S	113-73-5	Antibiotic	Inquiry
1-deoxynojirimycin	19130-96-2	Antidiabetics	Inquiry
Aureobasidin A	127785-64-2	Antifungal	Inquiry
Atpenin A5	119509-24-9	Antifungal	Inquiry
Rezafungin	1396640-59-7	Antifungal	Inquiry
Anidulafungin	166663-25-8	Antifungal	Inquiry
Ascomycin	104987-12-4	Immunosuppressant	Inquiry
Everolimus	159351-69-6	Immunosuppressant	Inquiry
Didemnin B	77327-05-0	Oncology	Inquiry
Staurosporine	62996-74-1	Oncology	Inquiry
Marizomib	437742-34-2	Oncology	Inquiry
Irofulven	158440-71-2	Oncology	Inquiry
Midostaurin	120685-11-2	Oncology	Inquiry
Geldanamycin	30562-34-6	Oncology	Inquiry
Fumagillin	23110-15-8	Oncology, Immunosuppressant	Inquiry
Plitidepsin	137219-37-5	Oncology, Antiviral	Inquiry
Brefeldin A	20350-15-6	Oncology, Antiviral	Inquiry
Thailanstatin A	1426953-21-0	Toxin, ADC payload	Inquiry
Leptomycin B	87081-35-4	Toxin, ADC payload	Inquiry
Fr901464	146478-72-0	Toxin, ADC payload	Inquiry
Sibiromycin	12684-33-2	Toxin, ADC payload	Inquiry
Calicheamicin	108212-75-5	Toxin, ADC payload	Inquiry
Vitamin K2 (Menaquinone-7)	2124-57-4	Healthcare Product	Inquiry
PQQ disodium salt	122628-50-6	Healthcare Product	Inquiry
Ectoine	96702-03-3	Cosmetic	Inquiry
Hyaluronic acid sodium salt	9067-32-7	Cosmetic	Inquiry
Orlistat	96829-58-2	Others	Inquiry
Cerulenin	17397-89-6	Antifungal, Oncology	Inquiry

Our Advantages

Over 20 years of experience in traditional strain culture and fermentation production.
Advanced fermentation process and modern fermentation facilities.
One-stop fermentation, analysis and purification service for desired metabolites.
Complete strain expression systems cover bacterial systems and eukaryotic systems.
Various valuable secondary metabolites fermentation.
Large-scale fermentation capability to meet the requirements of industrial production
Comprehensive analytical capabilities for compound characterization.
Cost-effective and high-quality products.

Our Methods

Strain development and improvement

Mutation: mutation is an alteration in the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA.
Gene cloning: Genes may be transferred between unrelated strains which are producers of known substances
Genetic recombination: exchange of genetic material occurs between different organisms
Strains selection: random selection or screening from the surviving population to define improved strain; identification of improved strains through assay of fermentation broth for products

High-throughput screening

Scale-up fermentation and commercial fermentation

Fermentation downstream process optimization

Process characterization
Stability development
Recovery and purification of fermentation products

Compound characterization: GC-MS, LC-MS, NMR, XRD, etc.

Project Workflow

Customer advisory
Project discussion, fermentation formulation (customers can provide fermentation strains)
Strain development and improvement
Lab-scale fermentation and scale-up fermentation
Targeted-compounds extraction and purification
Product Delivery