Fermentation Purification Service

In order to successfully separate and isolate the intended products from a complex combination of molecules that are formed during fermentation, the process of fermentation purification is necessary. Microorganisms are used in fermentation to produce the desired products, which are often present in a highly complex mixture of several chemical substances, biomass, and even cell detritus.

The Techniques in Fermentation Purification

Chromatography: Compounds are separated via chromatography according to their special qualities, such as size, charge, or affinities to particular molecules. Affinity chromatography, size exclusion chromatography, and ion exchange chromatography are some of the methods.
Ultrafiltration: Certain molecules are removed from the fermentation broth based on their size after being passed through a membrane.
Precipitation: This can be accomplished by methods like salting out, in which the addition of salts causes the products to precipitate out of solution, or by adding additional compounds that interact only with the desired products.

Why Fermentation Purification

Using a variety of highly specialized separation techniques, including chromatography, ultrafiltration, and precipitation, the major goal of fermentation purification is to successfully separate and isolate the desired products from these extremely complex mixtures.

Greater purity: It is possible to selectively eliminate undesirable substances and impurities from the finished product, giving the desired products a higher degree of purity.
Increased efficacy: Purification guarantees that the targeted products are free of impurities that could affect their performance or safety, making it a very trustworthy and effective option for use.
Scalability: Fermentation purification techniques are extremely scalable, allowing for the purification of significant amounts of the required products, allowing for the production of high-quality goods on a large scale.

The General Steps of Fermentation Purification

Depending on the specific product and purification techniques employed, the steps involved in fermentation purification can be complex and multifaceted. In general, however, the general steps of fermentation purification including:

Fermentation Purification Service

What Molecules Benefit from Fermentation Purification Services?

Fermentation purification services can be utilized to purify a wide variety of molecules produced through fermentation. Some of the molecules that can benefit from this process include:

Antibiotics
Enzymes
Proteins: e.g. insulin, growth hormone, and antibodies
Organic acids: e.g. citric acid, lactic acid, and acetic acid
Polysaccharides: e.g. xanthan gum and alginate

The Development of Fermentation Purification Processes

Characterization of the desired products
Selection of purification techniques
Optimization of process parameters
Validation of fermentation purification process
Scale-up of fermentation purification process
Purification process monitoring and control

Why Choose BOC Sciences' Fermentation Purification Service?

Microporous adsorption resins and ion exchange resins with high adsorption capacity, quick exchange speed, and stable chemical properties
Chromatography and membrane technology combined with high-efficiency green separation technology
Design and implementation of complex product separation and purification process
Preparation of standard of compound and the related impurities
Equiped with centrifuge, membrane system, chromatography, drying (spray & freeze-drying)