Strain Systems For Fermentation

As a leading contract development and manufacturing company, BOC Sciences has extensive experience in microbial strain fermentation to produce a variety of valuable molecules. Our strains systems have been constructed using the most advanced methods and tools from molecular and synthetic biology, in order to improve strain performance and enhance metabolism. BOC Sciences provides customized microbial fermentation services; we elect appropriate microbial strains for fermentation R&D or microbial production specific to our customer's project needs.

Prokaryotic Systems

Eukaryotic Systems

Introduction of Microbial Strains Fermentation

Microorganisms can serve as cell plants for the bio-based production of chemicals and materials. However, in most cases, microorganisms isolated from nature cannot efficiently produce the biological products we need. While with biotechnology, it is possible to enhance bioproducts formation at a cellular level and upregulate bioprocesses utilizing metabolic engineering and synthetic biology.

Microbial strains have been constructed to establish metabolic pathways for handling various applications. Meanwhile, fermentation is a metabolic process in which an organism converts carbohydrates into alcohol or acids. Metabolic engineering is a powerful technique for cellular and metabolic modification to achieve biological product upregulation using various tools, including recombinant DNA technology. Recently, an increasing number of synthetic biology tools have been developed, combined with metabolic engineering, to optimize microbial strains' performance, such as efficient enzymatic cascade reactions and enhanced metabolic capacity.

What Can We Do?

With over 20 years of strain development experience and advanced cell culture technologies, BOC Sciences has built comprehensive strain expression systems to genetically manipulate various strains and enhance the overexpression of target molecules. Our product list includes proteins, antibodies, industrial enzymes, and other small molecule compounds (antibiotics, peptides, oligonucleotides, etc.), which can be used as active pharmaceutical components (APIs).

BOC Sciences has the ability to convert a variety of traditional strains into engineered strains and provide one-stop fermentation CDMO services from laboratory scale to industrial scale fermentation services. Our strain systems cover both prokaryotes (E. coli, B. Subtilis, Streptomyces spp.) and eukaryotes (yeast, insect cells, and mammalian cells), thus supporting our customer's fermentation development in a wide range of applications, including metabolic research and microbial production.

We can provide a variety of strain development services includes but are not limited to:

• Gene Mutation Service
• Genetic Recombination Service
• Gene Overexpression Service
• Gene Editing Service
• Transfection Service
• High-throughput Screening Service
• Directed Evolution Service

Our Advantages

• Over 20 years of experience in traditional strain technology.
• Complete strain expression systems cover bacterial and eukaryotic systems.
• Microbial host development and medium optimization.
• High-throughput screening and analytical technologies.
• Microbial strains are improved to transform into the industrialized strain with the characteristics of:
• Rapid growth
• Stabilized Genetic
• Cost-effective substrates
• Reduced cultivation cost
• Shorten fermentation period

Project workflow

• Customer advisory
• Project discussion
• Selection of suitable microbial host
• Strain and culture condition optimization
• Novel strain evaluation - transform primitive strains into industrialized strains
• Microbial fermentation services
• Project delivery