Cyclosporin Analogue Set

Cyclosporine EP Impurity B is a closely related co-metabolite of cyclosporin A. It has no immunosuppressive activity and has been used as a control to determine the role of immunosuppression in cyclosporin A pharmacology, especially in the treatment of parasitic infections.

The minor analogues of the cyclosporin family have immunological activity because they do not bind to immunophilins. It is an inhibitor of phorbol ester that effectively promotes tumors on mouse skin, and effectively inhibits calcium/calmodulin-dependent phosphorylation of EF-2 in vitro. It is an effective and selective formyl peptide receptor antagonist and formyl peptide-induced superoxide formation inhibitor.

Cyclosporin D is a group of nonpolar cyclic oligopeptides with immunosupppressant activity. Cyclosporin D is a minor analogue of the cyclosporin complex produced by Trichoderma.

A minor analogue of the cyclosporin complex produced by a number of fungal species, including trichoderma, tolypocladium, fusarium, nectria and acremonium. It has the immunosuppressant activity but has been much less extensively investigated than the major analogue, cyclosporin A. Cyclosporin C is a broad-spectrum antifungal agent against filamentous phytopathogenic fungi but no activity against bacteria or yeasts.

Cyclosporin A (Cyclosporine A) is an immunosuppressant that binds to cyclophilins, inhibiting calcineurin activity with an IC50 of 7 nM. It also inhibits CD11a/CD18 adhesion molecules.

Cyclosporin B is a minor analogue of the cyclosporin complex produced by Trichoderma. An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.