Bruceol benzoate
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| Category | Others |
| Catalog number | BBF-04882 |
| CAS | 105668-07-3 |
| Molecular Weight | 432.47 |
| Molecular Formula | C26H24O6 |
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Specification
| IUPAC Name | 2,5,5-trimethyl-9-oxo-1,3,4,4a,5,12b-hexahydro-2H,9H-2,12-epoxybenzo[c]pyrano[3,2-g]chromen-1-yl benzoate |
Properties
| Boiling Point | 558.2±50.0°C at 760 mmHg |
| Melting Point | 221°C |
| Density | 1.37±0.1 g/cm3 (Predicted) |
Reference Reading
1. Monovalent cation leaks in human red cells caused by single amino-acid substitutions in the transport domain of the band 3 chloride-bicarbonate exchanger, AE1
Lesley J Bruce, Hannah C Robinson, Hélène Guizouarn, Franck Borgese, Penny Harrison, May-Jean King, Jeroen S Goede, Suzanne E Coles, Daniel M Gore, Hans U Lutz, Romina Ficarella, D Mark Layton, Achille Iolascon, J Clive Ellory, Gordon W Stewart Nat Genet. 2005 Nov;37(11):1258-63. doi: 10.1038/ng1656. Epub 2005 Oct 9.
We identified 11 human pedigrees with dominantly inherited hemolytic anemias in both the hereditary stomatocytosis and spherocytosis classes. Affected individuals in these families had an increase in membrane permeability to Na and K that is particularly marked at 0 degrees C. We found that disease in these pedigrees was associated with a series of single amino-acid substitutions in the intramembrane domain of the erythrocyte band 3 anion exchanger, AE1. Anion movements were reduced in the abnormal red cells. The 'leak' cation fluxes were inhibited by SITS, dipyridamole and NS1652, chemically diverse inhibitors of band 3. Expression of the mutated genes in Xenopus laevis oocytes induced abnormal Na and K fluxes in the oocytes, and the induced Cl transport was low. These data are consistent with the suggestion that the substitutions convert the protein from an anion exchanger into an unregulated cation channel.
2. Effect of the methodology on circulating peptides determination and consequences on net flux measurements across the gastrointestinal tract of sheep
L Bernard, C F R Backwell, D Rémond, D Wilson, L A Bruce, V Buchan, J C MacRae Arch Tierernahr. 2002 Feb;56(1):13-21. doi: 10.1080/00039420214177.
Two methodologies for the measurement of peptide amino acids (PAA) in blood were compared to evaluate their effects on the measurement of the net flux of peptides across the gastrointestinal tract of sheep. These methods consisted of a chemical deproteinization of blood samples with sulfosalicylic acid (1.6 M, 0.1 ml for 1 ml of sample) or perchloric acid (1 M, 1 ml for 1 ml of sample) followed by ultrafiltration through a 3,000-Da cut-off filter (SSA + UF3 kD) or gel filtration through a Sephadex G-15 column (1,500-Da cut-off filter; PCA + G-15), respectively, prior to PAA analysis. Peptide concentrations as determined by amino acid concentrations before and after hydrolysis of samples were slightly greater with the SSA + UF3 kD (991 microM) than with the PCA + G-15 (605 microM) methodology. However, both methodologies gave similar net portal-drained viscera flux data in sheep fed on alfalfa pellets with histidine as the only significant uptake of peptide amino acid.
3. Properties of hot-melt extruded tablet formulations for the colonic delivery of 5-aminosalicylic acid
L Diane Bruce, Navnit H Shah, A Waseem Malick, Martin H Infeld, James W McGinity Eur J Pharm Biopharm. 2005 Jan;59(1):85-97. doi: 10.1016/j.ejpb.2004.06.007.
Hot-melt extruded tablets were prepared using Eudragit S 100 as the polymeric carrier to target delivery of 5-aminosalicylic acid (5-ASA) to the colon. Scanning electron microscopy, modulated differential scanning calorimetry and X-ray diffraction analysis of the hot-melt tablet extrudates demonstrated that 5-ASA remained crystalline and was homogeneously dispersed throughout the polymer matrix. A pre-plasticization step was necessary when incorporating triethyl citrate (TEC) into the formulation in order to achieve uniform mixing of the polymer and plasticizer, effectively reduce the polymer glass transition temperature (T(g)), and to lower the processing temperatures. The concentration of TEC in the extrudates not only influenced the processing temperature, but also influenced the drug release rates from the extruded tablets due to leaching of the TEC during dissolution testing. Citric acid monohydrate was found to plasticize Eudragit S 100, and when combined with TEC in the powder blend, the temperatures required for processing were reduced. Tablets containing citric acid released drug at a slower rate as a result of the suppression of polymer ionization due to a decrease in the micro-environmental pH of the tablet. The drug release profiles of the extruded tablets were found to fit both diffusion and surface erosion models.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
