Forskolin
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| Category | Others |
| Catalog number | BBF-05802 |
| CAS | 66575-29-9 |
| Molecular Weight | 410.50 |
| Molecular Formula | C22H34O7 |
| Purity | ≥98% |
Ordering Information
| Catalog Number | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| BBF-05802 | 100 mg | $298 | In stock |
Online Inquiry
Add to cartDescription
Forskolin is a naturally occurring diterpene that is produced by the Indian Coleus plant. It directly activates adenylyl cyclase through its catalytic subunit and is commonly used to raise levels of cAMP in a wide variety of intact cells and tissue preparations.
Specification
| Related CAS | 66428-89-5 |
| Synonyms | Coleonol; HL 362; L 75-1362B; NSC 357088; NSC 375489; (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-Naphtho[2,1-b]pyran-1-one; (-)-Forskolin; Colforsin; ForsLean |
| Storage | Store at -20°C |
| IUPAC Name | [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate |
| Canonical SMILES | CC(=O)OC1C(C2C(CCC(C2(C3(C1(OC(CC3=O)(C)C=C)C)O)C)O)(C)C)O |
| InChI | InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1 |
| InChI Key | OHCQJHSOBUTRHG-KGGHGJDLSA-N |
Properties
| Appearance | White Solid |
| Boiling Point | 519.9±50.0°C at 760 mmHg |
| Melting Point | 220-230°C |
| Density | 1.2±0.1 g/cm3 |
| Solubility | Soluble in Chloroform (Slightly), Methanol (Slightly) |
Reference Reading
1.Establishment and Characterization of Naïve Pluripotency in Human Embryonic Stem Cells.
Warrier S1, Popovic M1, Van der Jeught M1, Heindryckx B2. Methods Mol Biol. 2016 Apr 5. [Epub ahead of print]
Mouse embryonic stem cells are known to represent the naïve state of pluripotency, while human embryonic stem cells typically represented the primed state of pluripotency, characterized by a higher drift toward differentiation and some other disadvantages. Here we describe an efficient method for rapid, transgene free induction of the naïve pluripotent state in human by applying a novel combination of small molecules and growth factors in the culture medium (2i, LIF, basic fibroblast growth factor, ascorbic acid, and forskolin). Conversion of primed human embryonic stem cells towards the naive pluripotent state should be confirmed by a detailed characterization of the cells, as described in this chapter.
2.CREB regulates TNF-α-induced GM-CSF secretion via p38 MAPK in human lung fibroblasts.
Koga Y1, Hisada T2, Ishizuka T3, Utsugi M4, Ono A2, Yatomi M2, Kamide Y5, Aoki-Saito H2, Tsurumaki H2, Dobashi K6, Yamada M2. Allergol Int. 2016 Apr 21. pii: S1323-8930(16)30028-4. doi: 10.1016/j.alit.2016.03.006. [Epub ahead of print]
BACKGROUND: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that mediates eosinophilic differentiation, migration and survival, causing respiratory tract inflammation. GM-CSF is also known to be secreted from respiratory tract structural cells. However, the mechanisms of GM-CSF secretion have not been well established.
3.[Effect of Kanli Granule on Myocardial Mechanics in Pressure Overload Induced Diastolic Heart Failure Rats].
Liu YM, Wu DZ, Xu YY, Teng MZ, Jiang MX. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2016 Feb;36(2):196-202.
OBJECTIVE: To observe the effect of Kanli Granule (KG) on myocardial mechanics in pressure overload induced diastolic heart failure (DHF) rats.
4.The Labdane Ent-3-Acetoxy-Labda-8(17), 13-Dien-15-Oic Decreases Blood Pressure In Hypertensive Rats.
Simplicio JA1, Simão MR2, Ambrosio SR2, Tirapelli CR3. Arq Bras Cardiol. 2016 Apr 19. pii: S0066-782X2016005011102. [Epub ahead of print]
BACKGROUND: Labdane-type diterpenes induce lower blood pressure via relaxation of vascular smooth muscle; however, there are no studies describing the effects of labdanes in hypertensive rats.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
