MS-282a
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| Category | Enzyme inhibitors |
| Catalog number | BBF-03676 |
| CAS | 152158-04-8 |
| Molecular Weight | 635.91 |
| Molecular Formula | C37H65NO7 |
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Description
MS-282a is produced by the strain of Streptomyces tauricus. It inhibits calmodulin-dependent MLCK with an IC50 of 3.8 μmol/L. It has anti-gram-positive bacteria activity.
Specification
| Synonyms | MS-282-A |
| IUPAC Name | 5-[1-[5-[2-(dimethylamino)heptyl]oxolan-2-yl]ethyl]-2,6,11-trimethyl-14-propyl-4,13,19,20-tetraoxatricyclo[14.2.1.17,10]icosane-3,12-dione |
| Canonical SMILES | CCCCCC(CC1CCC(O1)C(C)C2C(C3CCC(O3)C(C(=O)OC(CC4CCC(O4)C(C(=O)O2)C)CCC)C)C)N(C)C |
| InChI | InChI=1S/C37H65NO7/c1-9-11-12-14-27(38(7)8)21-29-15-17-31(41-29)23(3)35-24(4)32-19-20-34(44-32)26(6)36(39)43-28(13-10-2)22-30-16-18-33(42-30)25(5)37(40)45-35/h23-35H,9-22H2,1-8H3 |
| InChI Key | XYDPOPJRWPLBNE-UHFFFAOYSA-N |
Properties
| Appearance | Colorless Oily Solid |
| Antibiotic Activity Spectrum | Gram-positive bacteria |
Reference Reading
1. MS-282a and MS-282b, new inhibitors of calmodulin-activated myosin light chain kinase from Streptomyces tauricus ATCC 27470
S Nakanishi, K Kita, Y Uosaki, M Yoshida, Y Saitoh, A Mihara, I Kawamoto, Y Matsuda J Antibiot (Tokyo). 1994 Aug;47(8):855-61. doi: 10.7164/antibiotics.47.855.
MS-282a and MS-282b were isolated from the culture broth of Streptomyces tauricus ATCC 27470 as inhibitors of smooth muscle myosin light chain kinase (MLCK). MS-282a and MS-282b inhibited the activity of chicken gizzard MLCK with IC50 values of 3.8 microM and 5.2 microM, respectively. Cyclic AMP-dependent protein kinase, cyclic GMP-dependent protein kinase and protein kinase C were not inhibited by 150 microM MS-282a at all. It is likely that MS-282a blocks MLCK activity by antagonizing calmodulin since 1) the compound inhibited calmodulin-dependent but not calmodulin-independent activity of MLCK; 2) the inhibition of MLCK was antagonized by increasing concentrations of calmodulin, and 3) the compound inhibited calmodulin-dependent cyclic nucleotide phosphodiesterase.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
