Sangivamycin hydrochloride
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Category | Antibiotics |
Catalog number | BBF-02862 |
CAS | 21090-35-7 |
Molecular Weight | 345.74 |
Molecular Formula | C12H15N5O5.HCl |
Purity | 95% |
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Description
Sangivamycin hydrochloride is a nucleoside (purine) antibiotic produced by the strain of Str. rimosus BA-90912. 0.02-0.05 μg/mL of Sangivamycin inhibits HeLa cells. It has weak inhibitory effect on sarcoma-180 and adenocarcinoma 755 in mice. It has obvious inhibitory effect on leukemia L-1210. When intraperitoneally administered, the drug binds to nucleic acids in tissues in mice through phosphorylation.
Specification
Related CAS | 18417-89-5 (free base) |
Synonyms | Sangivamycin monohydrochloride; 7H-Pyrrolo(2,3-d)pyrimidine-5-carboxamide, 4-amino-7-beta-D-ribofuranosyl-, monohydrochloride; 7-Deazaadenosine-7-carboxamide hydrochloride |
Storage | Store at 2-8°C under inert atmosphere |
IUPAC Name | 4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carboxamide;hydrochloride |
Canonical SMILES | C1=C(C2=C(N=CN=C2N1C3C(C(C(O3)CO)O)O)N)C(=O)N.Cl |
InChI | InChI=1S/C12H15N5O5.ClH/c13-9-6-4(10(14)21)1-17(11(6)16-3-15-9)12-8(20)7(19)5(2-18)22-12;/h1,3,5,7-8,12,18-20H,2H2,(H2,14,21)(H2,13,15,16);1H/t5-,7-,8-,12-;/m1./s1 |
InChI Key | WTSGTUMQZSEZIW-CCUUNMJDSA-N |
Properties
Appearance | Colorless Long Needle Crystal |
Antibiotic Activity Spectrum | Neoplastics (Tumor) |
Boiling Point | 810.4°C at 760 mmHg |
Melting Point | 254-255°C |
Solubility | Soluble in Methanol |
Reference Reading
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2