Sorbistin A1
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| Category | Antibiotics |
| Catalog number | BBF-02918 |
| CAS | 60534-70-5 |
| Molecular Weight | 397.42 |
| Molecular Formula | C15H31N3O9 |
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Description
It is an aminoglycoside antibiotic produced by the strain of Pseudomonas sorbicinii nov. sp. It has anti-gram-positive and negative bacteria effects. Sorbistin A1 has moderate antibacterial activity, but it is stronger than Sorbistin A2 and B. Sorbistin A1 has no anti-anaerobic effect, but it has anti-plant pathogenic bacteria effect. It has the property of resisting some aminoglycoside antibiotic passivase, so it has antibacterial effect on some strains resistant to aminoglycoside antibiotic.
Specification
| Synonyms | Antibiotic gla1; Antibiotic P 2563-I; Antibiotic BN 186A; Antibiotic P 2563P; Antibiotic BU 2183A; D-Glucitol, 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-((1-oxopropyl)amino)-alpha-D-glucopyranosyl)- |
| IUPAC Name | N-[(2S,3S,4S,5R,6R)-6-[(2S,3S,4R,5S)-1,4-diamino-2,5,6-trihydroxyhexan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]propanamide |
| Canonical SMILES | CCC(=O)NC1C(OC(C(C1O)O)OC(C(CN)O)C(C(CO)O)N)CO |
| InChI | InChI=1S/C15H31N3O9/c1-2-9(23)18-11-8(5-20)26-15(13(25)12(11)24)27-14(6(21)3-16)10(17)7(22)4-19/h6-8,10-15,19-22,24-25H,2-5,16-17H2,1H3,(H,18,23)/t6-,7+,8+,10+,11+,12-,13+,14+,15+/m0/s1 |
| InChI Key | JFNOZOIQSSNDRN-KLIZIYMWSA-N |
Properties
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria |
| Boiling Point | 815.8°C at 760 mmHg |
| Density | 1.46 g/cm3 |
| Solubility | Soluble in Water |
Reference Reading
1. Sorbistin, a new aminoglycoside antibiotic complex of bacterial origin. I. Production, isolation and properties
H Tsukiura, M Hanada, K Saito, K Fujisawa, T Miyaki J Antibiot (Tokyo). 1976 Nov;29(11):1137-46. doi: 10.7164/antibiotics.29.1137.
A strain of a new Pseudomonas species produced the aminoglycoside antibiotic complex, sorbistin, which was separated by ion-exchange chromatography into three bio-active components A1, A2 and B, and two bio-inactive components C and D. Sorbistins A1, A2 and B showed moderate intrinsic activity against a wide range of bacterial species and inhibited most of the aminoglycoside-resistant organisms. Sorbistin A1 exhibited the highest activity among the three bio-active components. Sorbistins showed low order of acute toxicity in mice.
2. Sorbistin, a new aminoglycoside antibiotic complex of bacterial origin. III. Structure determination
M Konishi, S Kamata, T Tsuno, K Numata, H Tsukiura J Antibiot (Tokyo). 1976 Nov;29(11):1152-62. doi: 10.7164/antibiotics.29.1152.
The structures of sorbistins A1, A2, B, C and D have been determined including stereo-chemistry. Sorbistins A1, A2 and B are composed of a 4-acyl-amino-4-deoxy-D-glucose and 1,4-diamino-1,4-dideoxy-D-sorbitol, the latter compound being hitherto undescribed in literature. Sorbistins C and D have the same aglycone of 1,4-diamino-1,4-dideoxy-D-sorbitol, which is linked with D-glucose and 4-amino-4-deoxy-D-glucose, respectively, through a glycosidic bond.
3. Chemical modification of sorbistin. I. N-acyl analogs of sorbistin
T Naito, S Nakagawa, Y Narita, H Kawaguchi J Antibiot (Tokyo). 1976 Dec;29(12):1286-96. doi: 10.7164/antibiotics.29.1286.
Sorbistin A1 (1b) and sorbistin B (1a), bioactive components of a new type of aminoglycoside antibiotic produced by a strain of Pseudomonas species, have been converted into a key intermediate 3 by blocking of the 1- and 4-amino groups of sorbistins with dimedone and subsequent deacylation of the 4'-N-acyl group. Some 4'-N-acyl analogs of sorbistin (1e approximately 1t) have been synthesized by 4'-N-acylation of 3 with an appropriate reactive derivative of carboxylic acids (mixed anhydride, acid chloride or activated ester) followed by deblocking of the protected group with bromine or sodium nitrite. Chemical interconversion of three natural sorbistins A1 (1b), A2 (1c) and B (1a) has been performed by this procedure. The 1-N-acyl (4a approximately 4c) and the 1,4'-N,N-diacyl analogs (6a approximately 6c) have been prepared by direct N-acylation of sorbistin D (1d) (the 4'-desacyl derivative) and sorbistin A1, respectively. On the other hand, the 4-N-acyl (5a and 5b) and the 4,4'-N,N-diacyl derivatives (7a and 7b) have been prepared by acylation and subsequent hydrogenolysis of 1-N-Cbz-sorbistin D (4b) and 1-N-Cbz-sorbistin A1 (6b), respectively. Determination of in vitro antimicrobial activity showed that the 4'-N-propionyl (1b) and the 4'-N-cyclopropylcarbonyl (1s) derivatives are the most active members of the 4'-N-acyl derivatives. Elongation and shortening of the side chain and introduction of functional groups decreased the activity. N-Acylation of the amino group at C-1 or at C-4 gave virtually inactive products.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
