Antibiotics

Thiostrepton, a kind of natural peptide thiazole antibiotic, has been found to be effective in restraining the protein synthesis and could also influence the cell cycle and lead to apoptosis in breast cancer cells. It is also resistant to gram-positive bacteria and mycobacteria.

Thiotropocin is produced by the strain of Pseudomonas sp. CB-104. It has anti-gram-positive bacteria and negative bacteria, fungi, mycoplasma effect, especially on the proteus, treponema, mycoplasma, and plant pathogenic fungi.

Tirandamycin A is originally isolated from Str. tirandis var. tirandis NRRL 3689, and it has anti-gram-positive bacteria effect.

It is originally isolated from Str. achromogenes var. tomaymyceticus A-2127. Tomaymycin is resistant to gram-positive bacteria and fungi, and has a weak effect on E. coli.

Trichostatin A, also known as TSA, is an HDAC inhibitor. TSA inhibits the eukaryotic cell cycle during the beginning of the growth stage. TSA can be used to alter gene expression by interfering with the removal of acetyl groups from histones (histone deacetylases, HDAC) and therefore altering the ability of DNA transcription factors to access the DNA molecules inside chromatin. It is a member of a larger class of histone deacetylase inhibitors (HDIs or HDACIs) that have a broad spectrum of epigenetic activities.

Tryptanthrin is a potent inhibitor of Cox-2, IDO and NOS II produced by the strain of Candida lipolytica CBS2070 2072 and it has the effect of resisting gram positive bacteria.

Tuberactinomycin B is a member of the tuberactinomycin family of antibiotics used for the treatment of multidrug-resistant tuberculosis. Tuberactinomycin B inhibits group I intron splicing and prokaryotic protein synthesis, and freezes bacterial ribosomes in either the pre-or post-translational state.

Tubulysin B is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates. It also has anti-fungal properties.

Tylosin is a 16-member-ring macrolide produced through the fermentation of Streptomyces fradiae, a species of actinobacteria found in soil. It is effective against gram-positive bacteria, Mycoplasma species and certain gram-negative bacteria. With other macrolides, tylosin inhibits protein synthesis by binding to the 50S subunit of the bacterial ribosome and disrupting aminoacyl-and peptidyl-tRNA transcription. This is believed to ultimately prevent the bacteria from reproducing.

It is produced by the strain of Bac. subtilis var. theronophilus. Urocanic acid has an inhibitory effect on Eichner's ascites pain in animals.

The major analogue of a family of cyclitol disaccharides isolated from streptomyces hygroscopicus var. Limoneus. It is a potent antifungal agent used to control fungi in crop production and acts as a potent inhibitor of trehalase, an important enzyme in carbohydrate storage and ultilisation in fungi.

Validamycin B is an impurity of Validamycin that is resistant to rice sheath blight disease and Pellicularia sasakii.

An impurity of Validamycin. Validamycin is an antibiotic and fungicide.

A hydrophobic cyclodepsipeptide with potent antitumour activity; a highly selective potassium ionophore; a biosensor to detect potassium efflux.

Tricyclic glycopeptide antibiotic. Inhibits cell wall synthesis in Gram-positive bacteria. Pharmacologically active in vivo.

It is originally isolated from Pacilomyces varioti var. antibioticu K-5201 (ATCC-13435). Pecilocin has anti-fungal and bacterial effects, but the anti-bacterial effect is weak.

The macrolide antibiotic isolated from a streptomyces sp. It is a potent inhibitor of mitochondrial ATP synthase complex acting on the F0 membrane sector. It is originally isolated as an antifungal agent.

The macrolide antibiotic isolated from a streptomyces sp. It is a potent inhibitor of mitochondrial ATP synthase complex acting on the F0 membrane sector. It is originally isolated as an antifungal agent.

It is produced by the strain of Myrothecium verrucaria NRRL 3003. Verrucarin A has the effect of anti-Gram-negative bacteria and fungi, inhibiting Newcastle disease virus, tobacco Mosaic virus, and S-37 sarcoma and Yoshida sarcoma in animals.

Verrucarin J is produced by the strain of Myrothecium verrucaria NRRL 3003. The ED50 of Verrucarin J on giant cell tumor P-815 cells was about 0.001 μg/mL.