Antibiotics

It is a new metabolite from mine-dwelling Penicillium vermiculatum. It is an antibiotic with cytotoxic effects.

It is a naphthoquinone antibiotic isolated from Streptomyces arenae. It has activity against gram-positive bacteria.

Neomycin trisulfate is an aminoglycoside antibiotic. It can be used to prevent and treat gastrointestinal infections caused by gram-negative bacteria such as Salmonella and Escherichia coli.

It is a β-lactone antibiotic that is found in Pseudomonas fluorescens and is active against Staphylococcus aureus, Streptococcus faecalis, Klebsiella pneumoniae and Pseudomonas vulgaris.

Dalbavancin is a semi-synthetic glycopeptide by introducing a positively charged lipophilic moiety in a previously unexplored region of the natural glycopeptide. This modification provides a longer in vivo half life, and improved in vitro activity against a variety of Gram-positive and multi-drug resistant isolates such as MRSA and MRSE.

FR-901463 is a potent cell cycle inhibitor isolated from Pseudomonas sp. No.2663. It exhibits potent antitumor activities against tumor cell lines via binding to the spliceosome and modulating pre-mRNA splicing.

FR-901465 is a potent cell cycle inhibitor isolated from Pseudomonas sp. No.2663. It exhibits potent antitumor activities against tumor cell lines via binding to the spliceosome and modulating pre-mRNA splicing.

Esperamicin A1 is an enediyne antineoplastic antibiotic hybrid containing an anthranilate moiety. Esperamicin A1 is isolated from the bacterium Actinomadura verrucosospora.

Neocarzinostatin chromophore is a macromolecular chromoprotein enediyne antitumor antibiotic produced by Streptomyces macromomyceticus.

Bafilomycins are a family of macrolide antibiotics isolated from Streptomycetes sp. They exhibits antitumor, antiparasitic, immunosuppressant and antifungal activity.

Subtilosin A is an antibiotic peptide produced by Bacillus subtilis 168.

Olivomycin is an antitumor antibiotic produced by Actinomyces (or Streptomyces) olivoreticuli. It is used for the treatment of testicular neoplasms, tonsillar tumors and reticulosarcoma with peripheral nodes.

Siomycin is a peptide antibiotic that interacts with the 50S ribosomal subunit and inhibits binding of factor G and aminoacyl-tRNA. It exhibits antitumor activity against certain cancer cell lines.

Tallysomycin is an antitumor antibiotic complex produced by actinomycetes strain No. E465-94 with antibacterial and antifungal activity. It consists of two major components, A and B.

Pseudouridimycin is a C-nucleoside analogue that selectively inhibits bacterial RNA polymerase. Pseudouridimycin is an antibiotic found in Streptomyces albus that has activity against Gram-positive and Gram-negative bacteria.

Megalomicins are a family of macrolide antibiotics produced by the soil bacterium Micromonospora megalomicea. They exhibit antiparasitic, antiviral and antibacterial activity, and are effective against both Gram-positive and Gram-negative bacteria.

Rhodomycin are a family of antibiotics produced by a red-pigmented mutant of Streptomyces griseus. They possess anti-gram-positive bacteria, anti-gram-negative bacteria and antifungal properties.

Ivermectin is a glutamate-gated chloride channel (GluCls) activator, which is used as an antiparasitic drug for the treatment of certain parasitic roundworm infections. Ivermectin inhibits the chloride channels of helminthic parasites and has been shown to have clinical efficacy for the treatment of onchocerciasis, strongyloidiasis, and ectoparasitic infection. Ivermectin is a mixture of mostly Ivermectin B1a (>80%) with some Ivermectin B1b (<20%), which are macrolides from Streptomyces avermitilis.