BU-4704
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Antibiotics |
| Catalog number | BBF-02756 |
| CAS | |
| Molecular Weight | 382.39 |
| Molecular Formula | C19H14N2O5S |
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Description
BU-4704 is produced by the strain of Aspergillus sp. No. FA2692. It has anti-gram-positive bacteria, anti-gram-negative bacteria and cryptococcus neoformans activity. The IC50 of human colorectal cancer cells (HCT-16) and murine melanoma were 0.63 and 4.3 μg/mL, respectively.
Specification
| Synonyms | 4-[(1Z,3Z)-2,3-Diisocyano-4-(4-methoxyphenyl)-1,3-butadien-1-yl]phenyl hydrogen sulfate |
| IUPAC Name | [4-[(1Z,3Z)-2,3-diisocyano-4-(4-methoxyphenyl)buta-1,3-dienyl]phenyl] hydrogen sulfate |
| Canonical SMILES | COC1=CC=C(C=C1)C=C(C(=CC2=CC=C(C=C2)OS(=O)(=O)O)[N+]#[C-])[N+]#[C-] |
| InChI | InChI=1S/C19H14N2O5S/c1-20-18(12-14-4-8-16(25-3)9-5-14)19(21-2)13-15-6-10-17(11-7-15)26-27(22,23)24/h4-13H,3H3,(H,22,23,24)/b18-12-,19-13- |
| InChI Key | AFDVXUYMZKBPPT-BKHHGCLFSA-N |
Properties
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria; neoplastics (Tumor) |
| Melting Point | 165-170°C |
Reference Reading
1. Induced production of N-formyl alkaloids from Aspergillus fumigatus by co-culture with Streptomyces peucetius
Karina M Zuck, Suzanne Shipley, David J Newman J Nat Prod. 2011 Jul 22;74(7):1653-7. doi: 10.1021/np200255f. Epub 2011 Jun 13.
Co-culture of the fungus Aspergillus fumigatus with the bacteria Streptomyces peucetius led to the induction of production of formyl xanthocillin analogues. This mixed fermentation yielded two new metabolites, fumiformamide (1) and N,N'-((1Z,3Z)-1,4-bis(4-methoxyphenyl)buta-1,3-diene-2,3-diyl)diformamide (2), together with two known N-formyl derivatives and the xanthocillin analogue BU-4704. The structures were determined by spectroscopic methods and by comparison with literature. Cytotoxic activity of all the analogues was tested on the NCI-60 cell line screen, and compound 2 exhibited significant activity against several cell lines. The analogues did not show antimicrobial activity.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
