Antibiotics

Novobiocin is found to bind at a second ATP-binding site in the C-terminal domain of Hsp90, thus disrupting the interaction of both p23 and Hsp70 co-chaperones with the Hsp90 complex. (IC50=700μmol/L)

Nucleocidin is originally isolated from Str. calvus T 3018 and it is mainly resistant to bacteria, mycoplasma and protozoa.

An unusual heterocyclic metabolite isolated from several streptomyces species; possesses antiviral and antibacterial activity.

Ochracin has weak anti-Staphylococcus aureus effect.

It is originally isolated from Str. griseoflavus subsp. zamamiensis. It can resist gram-positive bacteria and inhibit leukemic cells.

Oleandomycin is a 16-membered macrocyclic lactone originally isolated from Str. antibioticus. It has broad spectrum antibacterial activity.

A minor component of the oligomycin complex isolated from selected strains of streptomyces; an inhibitor of mitochondrial F1F0-atpas; used as an eukaryotic ATP synthase inhibitor, induces apoptosis.

A minor component of the oligomycin complex isolated from selected strains of streptomyces; an inhibitor of mitochondrial F1F0-atpas; used as an eukaryotic ATP synthase inhibitor, induces apoptosis.

Ophiobolin A is the dominant member of a class of phytotoxic metabolites produced by plant pathogenic fungi. It is resistant to gram-positive bacteria, mycobacteria and fungi.

A minor member of a class of phytotoxic metabolites produced by bipolaris and other genera of plant pathogenic fungi; acts by inhibiting calmodulin action in calcium regulation.

A member of the ophiobolin class of phytotoxic metabolites produced by many species of the genus bipolaris; inhibits human CCR5 binding to the envelope protein gp120 and CD4 that mediates HIV-1 entry into cells.

Reductiomycin is produced by the strain of Str. griseorubiginosus S551. It can resist gram-positive bacteria, fungi and some yeast. It also inhibits the proliferation of chicken Newcastle disease virus.

A rare, boat-shaped, pentacyclic polyketide isolated from several species of streptomyces; exhibits weak antibacterial activity against gram-positive and gram-negative bacteria; exhibits potent cytotoxic activity against tumour cell lines in vitro; inhibits growth, and nucleic acid and protein synthesis in bacillus subtilis.

Resorcinomycin A is produced by the strain of Streptoverticillum roseoverticillatum. It has strong anti-mycobacterium effect and weak anti-mycoplasma effect.

Rifaximin EP Impurity B is an impurity of Rifaximin. Rifaximin is a semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. It also acts as a pregnane X receptor (PXR) agonist. It is approved for the treatment of traveler's diarrhea, irritable bowel syndrome, and hepatic encephalopathy.

Rifaximin EP Impurity C is an antibacterial drug which functions by inhibiting bacterial RNA polymerase (RNAP), is an impurity of Rifaximin. It also has anti-gram-positive bacterial and mycobacterium activities.

It has antifungal effect, and it can inhibit 50% of mast cell tumor P815 cells at 0.001 μg/mL in vitro.

An antibacterial pigment isolated from streptomyces davawensis; an anti-metabolite of riboflavin; mimic riboflavin in flavin biosynthesis; an important regulator of bacterial gene expression by binding to untranslated regions of RNA, so-called ribo-switching sites.

β-Rubromycin is a quinone antibiotic originally isolated from Streptomyces. It is effective against Gram-positive bacteria. It inhibits the growth of HMO2, KATO-III, and MCF-7 cells with GI50 values of 0.5, 0.84, and <0.1 μM, respectively. β-rubromycin also inhibits HIV-1 reverse transcriptase activity.

An intense yellow pigment produced by some species of penicillium, aspergillus and the fungal symbiotants of some lichens; shows antibacterial and insecticidal activity; an inhibitor of RNA Polymerase and Rnase.