Antibiotics

Triostin C is produced by the strain of Str. triostinicus S-2-210. Triostin C exhibited anti-gram-positive bacteria and mycobacteria activity, and had a strong inhibitory effect on Miyono adenocarcinoma, Ridgway osteosarcoma, Mecca lymphoid sarcoma and leukemia.

Tripropeptin A is a cyclic peptide antibiotic originally isolated from Lysobacter sp. BMK333-48F3. It has anti-Gram-positive bacteria activity against Staphylococcus (including MRSA), Streptococcus and Enterococcus, with MIC of 0.78-12.5μg/mL.

Tripropeptin B is a cyclic peptide antibiotic originally isolated from Lysobacter sp. BMK333-48F3. It has anti-Gram-positive bacteria activity against Staphylococcus (including MRSA), Streptococcus and Enterococcus, with MIC of 0.78-12.5μg/mL.

Tripropeptin C is a cyclic peptide antibiotic originally isolated from Lysobacter sp. BMK333-48F3. It has anti-Gram-positive bacteria activity against Staphylococcus (including MRSA), Streptococcus and Enterococcus, with MIC of 0.78-12.5μg/mL.

It is an antibiotic with anti-tumor effects originally isolated from Aclacinomycin KE303.

It is produced by the strain of Aspergillus fumigatus. Trypacidin has anti-protozoal and spirochete effects, but the effect on the latter is weak.

Tuberactinomycin A is produced by the strain of Streptoverticillium griseoverticillatus var. tuberacticus B-386. It is effective against mycobacteria, but less effective against gram-positive and gram-negative bacteria.

Tubulysin C is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin C is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis.

Tubulysin D is a tetrapeptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. It displays potent antitumor activity and leads to cell cycle arrest and apoptosis by inhibiting tubulin polymerization with an IC50 of 1.7 μM. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range.

Tylopeptin A is originally isolated from Tylopilus neofelleus and it has anti-gram-positive bacteria activity.

Tylopeptin B is originally isolated from Tylopilus neofelleus and it has anti-gram-positive bacteria activity.

Tyrocidine A is a peptide antibiotic originally isolated from Bac. brevis. It is resistant to gram-positive bacteria and protozoa as well as to a lesser degree to gram-negative bacteria, and it is also resistant to yeast.

Tyrocidine B is a peptide antibiotic originally isolated from Bac. brevis. It is resistant to gram-positive bacteria and protozoa as well as to a lesser degree to gram-negative bacteria.

Tyrocidine C is a peptide antibiotic originally isolated from Bac. brevis. It is resistant to gram-positive bacteria and protozoa as well as to a lesser degree to gram-negative bacteria.

Urauchimycin A is produced by the strain of Str. sp. Ni-80. It can inhibit the morphological differentiation of Candida albicans.

Urauchimycin B is produced by the strain of Str. sp. Ni-80. It can inhibit the morphological differentiation of Candida albicans.

It is originally isolated from Ustilaginoidea virens. Ustiloxin A can inhibit the polymerization of tubulin with an IC50 of 0.7 μmol/L, and it also inhibits mitosis in various human tumor cell lines.

It is originally isolated from Ustilaginoidea virens. Ustiloxin B can inhibit the polymerization of tubulin with an IC50 of 2.8 μmol/L, and it also inhibits mitosis in various human tumor cell lines.

Valanimycin is produced by the strain of Str. viridifaciens MG456-hF10 (FERMP8146). It has anti-Gram-positive bacteria and negative bacteria action and the effect on anti-Gram-negative bacteria is stronger. In vitro, the IC50 of it on murine leukemia cell line L-1210 was 0.79 μg/mL.

Vanoxonin is produced by the strain of Saccharopolyspora hirsuta. It can inhibit thymidylate synthase (IC50 = 0.7μg/mL). And the MIC of the complex against L-1210 and Ehrlich ascites cancer cells was 25 μg/mL.