Bioactive by-products

X-14885A is a divalent cation ionophore produced by a Streptomyces culture isolated from soil sample collected in Wyoming. It is active against gram-positive bacteria and Treponema.

Decarestrictin A is a cholesterol biosynthesis inhibitor with a Decanolide structure produced by Penicillum sunplicissimum and Pen. corylophilufn.

It is produced by the strain of Aspergillus sp. FH-A 6357. It has the inhibitory effect of cholesterol, and has weak anti-influenza virus A (MIC is 44 μg/mL) and sticky virus activity.

It is produced by the strain of Pseudaxinyssa cantharella. It can inhibit protein biosynthesis and has anti-tumor effect.

It is produced by the strain of Forme juniperinus. It has anti-gram positive bacterium, negative bacterium (weak), and mould (weak) activity, and it also has activity against flu virus PR-8. Human serum could reduce its activity.

Originally is isolated from galiella rufa as a plant growth regulator; also inhibits IL-6 induced SEAP expression with IC50 values of 250-500 nm, blocking the binding of the activated stat3 dimers to their DNA binding sites without inhibiting the tyrosine and serine phosphorylation of the stat3 transcription factor.

A thiopeptide antibiotic isolated from a streptomyces sp.; a potent activator of the tipa gene; a bacterial transcription regulator involved in multidrug resistance; displays a 10-fold selectivity for bacteria over mammalian cells lines; closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, foxm1.

A pyranone isolated from streptomyces sp.; an extremely potent autoregulator of the sporulation of the producing strain, and spores of closely related species.

A pyranone isolated from streptomyces sp.; a potent autoregulator of the sporulation of the producing strain, and spores of closely related species.

Midecamycin A2 is a macrolide compound produced by Streptomyces mycarofaciens. It has strong anti-Gram-positive bacteria and weak anti-Gram-negative bacteria, mycobacteria and fungi activity. Cross-resistance with erythromycin.

Midecamycin A3 is a macrolide compound produced by Streptomyces mycarofaciens. It has strong anti-Gram-positive bacteria and weak anti-Gram-negative bacteria, mycobacteria and fungi activity. Cross-resistance with erythromycin.

Midecamycin A4 is a macrolide compound produced by Streptomyces mycarofaciens. It has strong anti-Gram-positive bacteria and weak anti-Gram-negative bacteria, mycobacteria and fungi activity. Cross-resistance with erythromycin.

Mycoplanecin C is a cyclic peptide compound produced by Actinoplanes aivajinensis subsp. mycoplanecinus.

Mycoplanecin D is a cyclic peptide compound produced by Actinoplanes aivajinensis subsp. mycoplanecinus.

Mycotrienol I is a polyene macrolide compound produced by Str. rishiriensis T-23. It has anti-fungal and anti-leukemia activity.

Mycotrienol II is a polyene macrolide compound produced by Str. rishiriensis T-23. It has anti-fungal and anti-leukemia activity.

Nocathiacin I is produced by the strain of Nocardia sp. WW-12651. It is highly resistant to gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP) and multidrug resistant Enterococcus faecalis (MREF).

Oganomycin A is produced by the strain of Str. oganonensis Y-G 19Z. It is more stable than cephalosporin and resistant to gram-positive and negative bacteria. And it is more effective against gram-negative bacteria than gram-positive bacteria.

Oganomycin B is produced by the strain of Str. oganonensis Y-G 19Z. It is more stable than cephalosporin and resistant to gram-positive and negative bacteria. And it is more effective against gram-negative bacteria than gram-positive bacteria.

Quinocitrinine B is produced by the strain of Penicillum citrinum Thom 1910. It has moderate anti-gram positive and negative bacterial and fungal activity. And it also shows moderate antiproliferative activity to L-929, K-562 and HeLa cells.