Bioactive by-products

TAN-1511B is a lipopeptide antibiotic isolated from the culture broth of Streptosporangium amethystogenes subsp. fukuiense AL-23456. It induced the secretion of both granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF).

TAN-1511C is a lipopeptide antibiotic isolated from the culture broth of Streptosporangium amethystogenes subsp. fukuiense AL-23456. It induced the secretion of both granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF).

TMC-49A is a transcriptional up-regulator of low density lipoprotein receptor. It is produced by Streptomyces sp. AS1345. It enhanced the synthesis of LDL receptor in human hepatoma HepG2 cells as assessed by a receptor binding assay.

TMC-52A is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 13 nM.

TMC-52B is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 10 nM.

TMC-52C is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 10 nM.

TMC-52D is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 6 nM.

Roridin E is a macrocyclic trichothecene mycotoxin that has been found in M. verrucaria. It exhibits anticancer activity against various cancer cell lines.

Trichostatin RK is a trigustatine derivative produced by the strain of Streptomyces sp. RK98-A74. It can induce luciferase, but its activity is lower than that of trigustatin.

Tryprostatin B is a natural compound isolated from Aspergillus fumigatus and arrests cell cycle progression at the G2/M phase.

Tuberin is produced by the strain of Str.amakusaensis 10-101 and it is resistant to mycobacteria.

Ustilipid A is originally isolated from Ustilago maydie DSM 11494. It has the activity of antagonizing dopamine D1 and D2 receptors with the IC50 (μg/mL) of 30 and 5, respectively.

Ustilipid B is originally isolated from Ustilago maydie DSM 11494. It has the activity of antagonizing dopamine D1 and D2 receptors with the IC50 (μg/mL) of 16 and 7, respectively.

Bu-2841-10 is a cyclic ester peptide originally isolated from K-341-B7. It has activity against gram-positive bacteria.

It is originally isolated from Acremonium sp. MT70646. CRM646-A had a strong inhibitory effect on the movement of B16-H10 melanoma cells with IC50 of 15 μmol/L.

It is originally isolated from Acremonium sp. MT70646. CRM646-B had a strong inhibitory effect on the movement of B16-H10 melanoma cells with IC50 of 30 μmol/L.

It is produced by the strain of Stachyborrys sp. It has antimicrobial and antifungal activity.

It is produced by the strain of Stachyborrys sp. It has antimicrobial and antifungal activity.

It is a trihydrofuran derivative with cytotoxicity produced by the strain of Myceliophthora lutea TF-0409. It has very weak anti-staphylococcus aureus activity. In cell culture, its cytoplasmic activity against HL 60, P388, T24, HeLa and A549 was 8-10 times weaker than adriamycin, but its cytoplasmic activity against HL 60/ADM was stronger than adriamycin (IC50 is 2.0 μg/mL). IC50 is 0.1 μg/mL.

It is a trihydrofuran derivative with cytotoxicity produced by the strain of Myceliophthora lutea TF-0409. It has very weak anti-staphylococcus aureus activity. In cell culture, its cytoplasmic activity against HL 60, P388, T24, HeLa and A549 was 8-10 times weaker than adriamycin, but its cytoplasmic activity against HL 60/ADM was stronger than adriamycin (IC50 is 2.0 μg/mL). IC50 is 0.2 μg/mL.