Enzyme inhibitors

It is a phospholipase C (PLC) inhibitor originally isolated from fungal MT51005.

EI-1507-1 is produced by the strain of Streptomyces sp. E-1507. It had weak antibacterial activity, and it inhibited ICE with an IC50 of 0.23 μmol/L.

EI-1507-2 is produced by the strain of Streptomyces sp. E-1507. It had weak antibacterial activity, and it inhibited ICE with an IC50 of 0.42 μmol/L.

It is produced by the strain of Streptomyces sp. E-1511. EI-1511-3 inhibited recombinant human ICE with an IC50 of 0.09 μmol/L.

It is produced by the strain of Streptomyces sp. E-1511. EI-1511-5 inhibited recombinant human ICE with an IC50 of 0.38 μmol/L.

It is produced by the strain of Streptomyces sp. E-1625. EI-1625-2 inhibited recombinant human ICE with an IC50 of 0.2 μmol/L.

It is originally isolated from Farrowia sp. E-1941. EI-1941-1 inhibited recombinant human ICE with an IC50 of 0.086 μmol/L. It also inhibits elastase and cathepsin.

It is originally isolated from Farrowia sp. E-1941. EI-1941-2 inhibited recombinant human ICE with an IC50 of 0.006 μmol/L. It also inhibits elastase and cathepsin.

EI-2128-1 is originally isolated from Penicillum sp. E-2128. It selectively inhibited ICE, and the IC50 of recombinant human ICE was 0.59 μmol/L. It also has anti-Gram-positive bacteria such as Bacillus subtilis, Staphylococcus aureus and Enterococcus enterococcus.

EI-2346 is originally isolated from Streptomyces sp. E-2346. It selectively inhibited ICE, and the IC50 of recombinant human ICE was 3.9 μmol/L. It also inhibits elastase and cathepsin.

F-10748 C1 is originally isolated from Lophodermium sp. SANK 18496. It had inhibitory activity against fungal 1,3-β-glucan synthase with IC50 of 0.2-2 μg/mL.

F-10748 C2 is originally isolated from Lophodermium sp. SANK 18496. It had inhibitory activity against fungal 1,3-β-glucan synthase with IC50 of 0.2-2 μg/mL.

F-11334-A1 is a membrane binding inhibitor of N-SMase originally isolated from Acremonium murorum. Under neutral conditions, the IC50 (μg/mL) of it against rat brain microsomal N-SMase was 7.5.

F-11334-A2 is a membrane binding inhibitor of N-SMase originally isolated from Acremonium murorum. Under neutral conditions, the IC50 (μg/mL) of it against rat brain microsomal N-SMase was >200.

F-11334-A3 is a membrane binding inhibitor of N-SMase originally isolated from Acremonium murorum. Under neutral conditions, the IC50 (μg/mL) of it against rat brain microsomal N-SMase was >200.

F-11334-B1 is a membrane binding inhibitor of N-SMase originally isolated from Acremonium murorum. Under neutral conditions, the IC50 (μg/mL) of it against rat brain microsomal N-SMase was 3.6.

F-11334-B2 is a membrane binding inhibitor of N-SMase originally isolated from Acremonium murorum. Under neutral conditions, the IC50 (μg/mL) of it against rat brain microsomal N-SMase was 3.2.

It is produced by the strain of Trichopezizella barbata SANK 25395. F-12509A has competitive inhibitory activity against sphingosine kinase, and the Ki value is 18μmol/L.

It is produced by the strain of Penicillum sp. F13459. F13459 had inhibitory activity against inosine 5'-phosphate dehydrogenase and it can inhibit the synthesis of Newcastle disease virus (NDV) hemagglutinin (HA) at 25 μg/mL.

It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817.