Enzyme inhibitors

It is produced by the strain of Streptomyces sp. MQ22. It has the inhibitory effect of dexamethasone-glucocorticoid receptor. IC50 is 1.5 X 10-5 mol/L (rat liver cytosol). It has the anti-tumor cell activity, inhibits rat leukemia cell L1210 with IC50 of 0.08 μg/mL.

It is produced by the strain of Streptomyces diastatochromogenes. It has antifungal, antiviral, immunosuppressive, cytotoxic and other activities, and is a specific inhibitor of V-type ATPase (Ki=0.02 nmol/L), which is an important tool for biochemical research.

It is produced by the strain of Streptomyces diastatochromogenes. It has antifungal, antiviral, immunosuppressive, cytotoxic and other activities, and is a specific inhibitor of V-type ATPase, which is an important tool for biochemical research.

It is produced by the strain of Streptomyces diastatochromogenes. It has antifungal, antiviral, immunosuppressive, cytotoxic and other activities, and is a specific inhibitor of V-type ATPase, which is an important tool for biochemical research.

It is produced by the strain of Penicillum cyclopium and Pen. corymbiferum. Cyclopenin can inhibit the growth of plants. Cyclopenin acts as an inhibitor of acetylcholinesterase (AChE). Cyclopenin also has antibacterial activity against E. coli and M. pyogenes.

It is produced by the strain of Polypocladiurn inflatum. It has a strong immunosuppressive action, but also has anti-inflammatory and weak antifungal effects. The mechanism of immunosuppression is the combination of cyclosporin A and cyclosporin-binding protein in T cells, which inhibits the activity of Calcineurin, and then impedes the transposition of intracellular transcription factors into the nucleus, and inhibits the interleukin-2 transcription, resulting in immunosuppression. It is mainly used for kidney transplantation, bone marrow and heart transplantation, and is one of the most important immunosuppressive agents in clinical application.

It is produced by the strain of Helminthosporium dematioideum, Coriolus vernicipes. It has many biological activities, such as inhibiting cytokinesis reversibly, inhibiting megasophil endocytosis and exocytosis. Cytochalasin A is an HIV protease inhibitor.

It is produced by the strain of Fomes tasmanicus. It inhibits the activity of Hydroxylases including tyrosine, tryptophan and phenylalanine.

It is produced by the strain of Bacillus cereus BMF 657-RF1. It can inhibit Dipeptidyl amino peptidase IV and immune enhancement effect.

It is produced by the strain of Pseudomonas sp.. It has the effect of lowering blood pressure and inhibiting barley germination.

It is produced by the strain of Streptomyces aburaviensis. It has the inhibitory effect on Esterases (IC50 is 0.56 μg/mL), Pancreatic lipase (IC50 is 0.003 μg/mL) and Cutinase on fungal cells.

It is produced by the strain of Streptomyces aburaviensis. It has the inhibitory effect on Esterases (IC50 is 0.00035 μg/mL), Pancreatic lipase (IC50 is 0.0008 μg/mL) and Cutinase on fungal cells.

It is produced by the strain of Pseudomonas pyocyanea, P. aeruginosa, P. methanica. HQNO is a quinolone inhibitor that blocks NADH oxidase (NADH) and Na+-dependent NADH-quinone reductase (NQR). It has weak anti-gram-positive bacterial activity. It can inhibit the microsomal respiratory chain and 5-lipoxygenase of cytochrome BC1 complex, and antagonize the antibacterial activity of dihydrostreptomycin.

It is produced by the strain of Pseudomonas pyocyanea, P. aeruginosa, P. methanica. It has weak anti-gram-positive bacterial activity. It can inhibit the microsomal respiratory chain and 5-lipoxygenase of cytochrome BC1 complex, and antagonize the antibacterial activity of dihydrostreptomycin.

It is produced by the strain of Streptomyces lavendulae. Deoxymannojirimycin is a powerful enzyme inhibitor.

It is produced by the strain of Streptomyces sp. MJ7420NF5. Dephostatin inhibits the activity of protein tyrosine phosphatase, has an IC50 of 7.7 moL/L against PTPase prepared from human tumor T cell lines, and it inhibits the growth of Jokat cells, and has a weak antibacterial activity (MIC 50~ 100 μg/mL).

Dicloxacillin, a β-lactamase resistant penicillin similar to oxacillin, used to treat infections caused by susceptible (non-resistant) Gram-positive bacteria.

Dihydromevinolin is an impurity in Lovastatin bulk drug. It is produced by the strain of Aspergollus terreus.

Folipastatin is a fungal metabolite that is produced by A. unguis. Folipastatin is also an inhibitor of phospholipase A2 (PLA2) with an IC50 of 39 μM.

Fosfomycin is produced by the strain of Streptomyces fradiae and Str. viridochromogenes. It competitively inhibits enol pyruvate transferase and blocks the early stages of bacterial cell wall synthesis. And it has anti-gram positive bacteria and negative bacteria activity.