Antibiotics

FR901469 is an antifungal antibiotic produced by fungal sp. No. 11243. It inhibits the activity of 1, 3-β-glucan synthase, and has strong anti-Candida albicans and Aspergillus fumigatus activity in vitro and in vivo.

FR901483 is originally isolated from Cladotryum sp. No. 11231. It has a strong immunosuppressive effect.

G-52 is originally isolated from Micromonospora zionesis. It has a wide antibacterial spectrum and is effective against the infection of Escherichia coli, Pseudomonas and Staphylococcus in mice.

It is an aminoglycoside antibiotic which has anti-gram-positive and anti-gram-negative activities.

It is produced by the strain of Cytophaga johnsonii. G 1499-2 can inhibit the growth of Flavobacterium, Staphylococcus aureus and Bacillus subtilis.

G2201-C is originally isolated from Streptomyces cattleya. It is resistant to Gram-positive bacteria and has a weak anti-Gram-negative activity.

GE 2270A is a thiopeptide antibiotic produced by the strain of Planobispora rosea. It inhibits bacterial protein synthesis and has anti-Gram-positive aerobic and anaerobic bacteria (MIC = 0.03-0.25 μg/mL) and Mycobacterium tuberculosis (MIC = 1 μg/mL) activities.

G7063-2 is produced by the strain of Streptomyces sp. It has anti-Gram-positive bacteria, negative bacteria and fungi activities.

It is originally isolated from Streptomyces sp. GERI-155. GERI-155 had anti-Gram-positive bacteria (MIC 0.09-12.5 μg/mL) and some Gram-negative bacteria, such as Pseudomonas aeruginosa and Salmonella typhimurium activities.

It is originally isolated from Streptomyces sp. GEX1. GEX1Q1 has no antibacterial activity but has cytotoxicity to some cancer cells.

It is originally isolated from Streptomyces sp. GEX1. GEX1Q2 has no antibacterial activity but has cytotoxicity to some cancer cells.

It is originally isolated from Streptomyces sp. GEX1. GEX1Q3 has no antibacterial activity but has cytotoxicity to some cancer cells.

A novel antifungal antibiotic GR 135402 has been isolated from a Graphium putredinis which inhibited protein synthesis in Candida albicans but not rabbit reticulocytes.

GTRI-BB is from Micromonospora sp. SA-246 with anti-gram-positive bacteria activity and cytotoxicity. The GI50 (μg/mL) of PC-3 (prostate), A549 (lung) and K562 (leukemia) cells were 0.21, 0.25 and 0.21 respectively.

IB-00208, a new cytotoxic polycyclic xanthone produced by Actinomadura sp. It also has anti-Gram-positive bacteria activity (MIC=0.09-1.4 nmol/L).

It is produced by the strain of Micromonospora L-25-ES25-008. Antibiotic IB 96212 had only antifungal activity against micrococcus luteus and particularly strong cytotoxicity against P388 with IC50 of 0.0001 μg/mL.

IC-202-A shows immunosuppressive activity, with IC50 of 3.6 μg/mL as determined by MLCR, and has a strong inhibitory effect on Blastogensis induced by ConA or lipopolysaccharide (LPS).

IC202B shows immunosuppressive activity, with IC50 of 3.6 μg/mL as determined by MLCR, and has a strong inhibitory effect on Blastogensis induced by ConA or lipopolysaccharide (LPS).

It is originally isolated from Cunninghamella sp. F-1490. ICM0201 can inhibit the formation of osteoclasts in mouse bone marrow cells with IC50 of 0.78 μg/mL.

IT-62-B is originally isolated from Streptomyces sp. IT-62. It had moderate anti-Gram-positive bacteria activity (MIC 6.25-12.5 μg/mL), and anti-L1210, P388, adriamycin-resistant P388 and KB tumor cells activity.