Enzyme inhibitors

Bacithrocin A is produced by the strain of Bacillus laterosporus Laubach NR 2988. The ED50 of the four components A, B, C and D were 48, 84, 80, 124X10-6 mol/L, and the reference antipain was 13X10-6 mol/L, respectively.

Bacithrocin B is produced by the strain of Bacillus laterosporus Laubach NR 2988. The ED50 of the four components A, B, C and D were 48, 84, 80, 124X10-6 mol/L, and the reference antipain was 13X10-6 mol/L, respectively.

Bacithrocin C is produced by the strain of Bacillus laterosporus Laubach NR 2988. The ED50 of the four components A, B, C and D were 48, 84, 80, 124X10-6 mol/L, and the reference antipain was 13X10-6 mol/L, respectively.

Bacithrocin D is produced by the strain of Bacillus laterosporus Laubach NR 2988. The ED50 of the four components A, B, C and D were 48, 84, 80, 124X10-6 mol/L, and the reference antipain was 13X10-6 mol/L, respectively.

Benadrostin is produced by the strain of Streptomyces flavovirens MH499-O'Flc. Poly-(adp-Ribose) synthetase was inhibited with IC50 of 35μmol/L.

Benarthin is produced by the strain of Streptomyces xanthophaeus MJ 244-SF1. It inhibited the activity of pyroglutaminase and competed with the substrate, and the inhibitory constant Ki and Km was 1.2x10-6 mol/L and 3.3x10-5 mol/L, respectively.

Benastatin A is produced by the strain of Streptomyces sp. MI 384-DF12. It can inhibit glutathione transferase (GST) activity.

Benastatin B is produced by the strain of Streptomyces sp. MI 384-DF12. It can inhibit glutathione transferase (GST) activity.

Benastatin C is produced by the strain of Streptomyces sp. MI 384-DF12. It can inhibit glutathione transferase (GST) activity.

(S)-a-Benzylmalic acid is produced by the strain of Penicillum sp. It can be used to inhibit carboxylpeptidase A and slightly inhibit carboxylpeptidase B.

Chlorogentisylquinone is produced by the strain of FOM-8108. The IC50 of inhibitory rat meningeal nSMase was 1.2μmol/L, and the IC50 of P388 cells was 7.6μmol/L.

It is produced by the strain of Streptomyces hygroscopicus and Str.lavendulae. Chymostatin A can be used to inhibit chymotrypsin, papain and other serine/cysteine endopeptidase.

It is produced by the strain of Circinotrichum falcatisporum RF-641. Cinatrin A has the activity of inhibiting phosphoesterase A2.

It is produced by the strain of Circinotrichum falcatisporum RF-641. Cinatrin B has the activity of inhibiting phosphoesterase A2.

It is produced by the strain of Circinotrichum falcatisporum RF-641. Cinatrin C1 has the activity of inhibiting phosphoesterase A2.

It is produced by the strain of Circinotrichum falcatisporum RF-641. Cinatrin C2 has the activity of inhibiting phosphoesterase A2.

It is produced by the strain of Circinotrichum falcatisporum RF-641. Cinatrin C3 has the activity of inhibiting phosphoesterase A2.

It is produced by the strain of Penicillum sp. AB 2089ZZD-62 (NRRL 22559). Citrinin hydrate is a human rhinovirus 3C protease inhibitor with the IC50 of 1.0 mmol/L.

Clavicoronic acid is produced by the strain of Clavicorona pyxidata. It can inhibit the reverse transcriptase activity of myeloblastocytosis virus (AMV) and Moloney mouse leukemia virus (MMuLV).

It is produced by the strain of Streptomyces clavuligerus. Clavulanic acid has a strong inhibition of β-lactamase activity, almost no antibacterial effect.